Ponderal behavior of rats fed an omegas 3, 6 and 9 enriched diet submitted to colon carcinogenesis induced by azoxymethane

• Published in: Acta cirurgica brasileira Vol. 28; no. 10; pp. 721 - 727
• Main Authors: Burlamaqui, Idália Maria Brasil, Dornelas, Conceição Aparecida, Brito, Lara Albuquerque de, Trindade, Jr, José Wilson Meireles, Sucupira, Rafael Moura e, Veras, Lara Burlamaqui, Azevedo, Orleâncio Gomes Ripardo de, Vasconcelos, Paulo Roberto Leitão, Rodrigues, Lusmar Veras
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01-10-2013
• Subjects: Animals; Azoxymethane; Body Weight - drug effects; Carcinogens; Colonic Neoplasms - chemically induced; Colonic Neoplasms - metabolism; Colorectal Neoplasms; Diet; Diet, High-Fat; Eating - drug effects; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-6 - administration & dosage; Fatty Acids, Unsaturated - administration & dosage; Food, Fortified; Injections, Intraperitoneal; Male; Oleic Acids - administration & dosage; Random Allocation; Rats; Rats, Wistar
• ISSN: 0102-8650; 1678-2674; 0102-8650
• DOI: 10.1590/S0102-86502013001000006

To assess weight changes in rats fed diets with different ratios of omegas 3, 6 and 9 submitted to colonic carcinogenesis induced by Azoxymethane (AOM).
Sixty rats with three weeks of life were distributed into five groups of specific diets containing 12 animals each: GI- Standard diet without administration of AOM, GII- Standard diet with administration of AOM; GIII- Hyperlipidic diet with administration of AOM; GIV-Normolipidic diet with administration of AOM; GV- Hypolipidic diet with administration of AOM. The weight and food intake of each group were assessed four times in each week throughout the experiment until euthanasia at 36th week.
GI and GII had no significant difference in weight. GI showed a significant increase when compared to GIII, GIV and GV. GII also showed a significant increase when compared to GIII, GIV and GV. When comparing intake of GI as compared to GII no significant difference was found, however such groups had higher intake than groups III, IV and V. There were found no difference in weight when comparing among rats with and without cancer within each groups: GII, GIII, GIV and GV.
Diets rich in omega 3, 6 and 9 reduced food intake and weight. Rats with colorectal cancer had no decrease in weight as compared to those without this condition in the same group.