Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 34; no. 3; pp. 661 - 666
• Main Authors: Cuellar-Rufino, Sergio, Navarro-Meza, Mónica, García-Solís, Pablo, Xochihua-Rosas, Irene, Arroyo-Helguera, Omar
• Format: Journal Article
• Language: English
• Published: Spain Grupo Arán 05-06-2017
• Subjects: Adolescent; Adult; Antioxidants - metabolism; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Hypertension, Pregnancy-Induced - metabolism; Iodine - urine; Mexico - epidemiology; Nutrition & Dietetics; Nutritional Status; Oxidative Stress - physiology; Pregnancy; Young Adult; Iodine deficiency. Pregnancy-induced hypertension. Oxidative stress. Antioxidant status; Oxidative stress; Antioxidant status; Iodine deficiency; Pregnancy-induced hypertension; Estado antioxidante; Hipertensión inducida por el embarazo; Deficiencia de yodo; Estrés oxidativo
• ISSN: 0212-1611; 1699-5198; 1699-5198
• DOI: 10.20960/nh.460

The antioxidant function of iodine and iodine deficiency as a risk factor of preeclampsia have been previously reported.
To analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD).
Fifty-seven pregnant women were recruited in the last trimester of pregnancy; 20 were diagnosed with hypertensive disease (HPD) of pregnancy and 37 were normotensive pregnant women. Urinary iodine concentration (UIC), TSH, free T4 (fT4), total antioxidant status (FRP), superoxide dismutase (SOD), catalase (CAT), and oxidative stress (TBARS) were evaluated by colorimetric methods.
UIC median for all pregnant women was 151.9 µg/l. The UIC for pregnant women with HPD was 50-149 µg/l, compared to 150-249 µg/l in normotensive women. No significant differences in levels of TSH and fT4 in normotensive pregnant compared with HPD women were found. Pregnant women with HPD had significant high levels of TBARS, and significant low levels of FRP, SOD, CAT and UIC compared to normotensive pregnant. In addition, pregnant women with optimal levels of UIC had a higher SOD activity (r = 0.354, p = 0.011), while iodine deficiency was associated with HPD (r = -0,281, p = 0.039). Similarly, pregnant women with HPD had a significant negative association with SOD activity (r = -0.702, p = 0.005), CAT (r = -0.409, p = 0.002), and FRP (r = -0.624, p = 0.003), and a positive association with TBARS (r = 0.744, p = 0.001).
Iodine contributes to redox balance during pregnancy; its deficiency is associated with HPD. This study shows the importance of iodine during pregnancy.