Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia

Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia

The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal noctur...

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Published in:São Paulo medical journal Vol. 122; no. 6; pp. 273 - 275
Main Authors: Figueiredo, Maria Stella, Vicari, Perla, Kimura, Eliza Yuriko Sugano, Antunes, Sandra Vallin, Yamamoto, Mihoko
Format: Journal Article
Language:English
Published: Brazil Associação Paulista de Medicina - APM 04-11-2004
Associação Paulista de Medicina
Subjects:
Acute Disease
Adult
Anemia, Aplastic - blood
Anemia, Aplastic - complications
Aplastic anemia
Disease
Fatal Outcome
Hemoglobin H
Humans
Leukemia, Myeloid - blood
Leukemia, Myeloid - etiology
Male
MEDICINE, GENERAL & INTERNAL
Myelodysplastic syndromes
Myelodysplastic Syndromes - complications
Myeloid leukemia
Time Factors
Anemia aplástica
Disease
Hemoglobina H
Myeloid leukemia
Aplastic anemia
Leucemia mielóide
Hemoglobin H
Doença
Síndromes mielodisplásicas
Myelodysplastic syndromes
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Abstract The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
AbstractList CONTEXTThe prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia.CASE REPORTWe report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin. CONTEXTO: O prognóstico da anemia aplástica grave melhorou com o advento do transplante de medula óssea e do tratamento imunossupressor com globulina antitimocitária. Em contraste com o sucesso destes protocolos, os estudos com seguimento a longo prazo mostraram a ocorrência de doenças clonais, tais como: hemoglobinúria paroxística noturna, síndrome mielodisplásica e leucemia aguda. RELATO DE CASO: Nós relatamos o primeiro caso descrito no Brasil de um paciente com anemia aplástica que evoluiu para síndrome mielodisplásica e leucemia mielóide aguda associada a presença de hemoglobina H e aumento da hemoglobina fetal.
The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In contrast to the success of these protocols, studies with long term follow-up have shown the occurrence of clonal diseases such as paroxysmal nocturnal hemoglobinuria, myelodysplastic syndrome and acute leukemia in aplastic anemia. CASE REPORT: We report the first case of a Brazilian patient with aplastic anemia who developed myelodysplastic syndrome and acute myeloid leukemia showing acquired hemoglobin H and increased fetal hemoglobin.
Author Vicari, Perla
Yamamoto, Mihoko
Antunes, Sandra Vallin
Figueiredo, Maria Stella
Kimura, Eliza Yuriko Sugano
AuthorAffiliation Universidade Federal de São Paulo
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  givenname: Maria Stella
  surname: Figueiredo
  fullname: Figueiredo, Maria Stella
  email: stella@hemato.epm.br
  organization: Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, Brazil. stella@hemato.epm.br
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  givenname: Perla
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  givenname: Mihoko
  surname: Yamamoto
  fullname: Yamamoto, Mihoko
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Cites_doi 10.1159/000206355
10.1111/j.1365-2141.1993.tb03055.x
10.1016/S0037-1963(00)90027-1
10.1111/j.1365-2141.1988.tb02382.x
10.1016/S0037-1963(00)90033-7
10.1016/S0009-8981(99)00186-2
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DocumentTitleAlternate Hemoglobinopatia H adquirida em um paciente com anemia aplástica e evolução para leucemia mielóide aguda
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Issue 6
Keywords Anemia aplástica
Disease
Hemoglobina H
Myeloid leukemia
Aplastic anemia
Leucemia mielóide
Hemoglobin H
Doença
Síndromes mielodisplásicas
Myelodysplastic syndromes
Language English
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Tichelli A (ref2) 1988; 69
Barrett J (ref6) 2000; 37
Tamura S (ref1) 1993; 84
Annino L (ref5) 1984; 72
Kudo S (ref4) 2000; 291
Tichelli, A; Gratwohl, A; Wursch, A; Nissen, C; Speck, B 1988; 69
Barrett, J; Saunthararajah, Y; Molldrem, J 2000; 37
Tamura, S; Kanamaru, A; Takemoto, Y; Kakishita, E; Nagai, K 1993; 84
Socié, G; Rosenfeld, S; Frickhofen, N; Gluckman, E; Tichelli, A 2000; 37
Kudo, S; Harigae, H; Watanabe, N 2000; 291
Annino, L; Di Giovanni, S; Tentori, L 1984; 72
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  contributor:
    fullname: Tamura S
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  publication-title: Semin Hematol
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  article-title: Late haematological complications in severe aplastic anaemia
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  publication-title: Br J Haematol
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  start-page: 41
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  article-title: Acquired hemoglobin H disease in a case of refractory anemia with excess of blasts (RAEB) evolving into acute nonlymphoid leukemia
  publication-title: Acta Haemat
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  publication-title: Clin Chim Acta
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Snippet The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In...
CONTEXT: The prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin....
CONTEXTThe prognosis of severe aplastic anemia has improved since the introduction of bone marrow transplantation and treatment with antithymocyte globulin. In...
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StartPage 273
SubjectTerms Acute Disease
Adult
Anemia, Aplastic - blood
Anemia, Aplastic - complications
Aplastic anemia
Disease
Fatal Outcome
Hemoglobin H
Humans
Leukemia, Myeloid - blood
Leukemia, Myeloid - etiology
Male
MEDICINE, GENERAL & INTERNAL
Myelodysplastic syndromes
Myelodysplastic Syndromes - complications
Myeloid leukemia
Time Factors
Title Acquired hemoglobin H disease in a patient with aplastic anemia evolving into acute myeloid leukemia
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