Parkinson's disease and dopamine transporter neuroimaging: a critical review
Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomograph...
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| Published in: | São Paulo medical journal Vol. 124; no. 3; pp. 168 - 175 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Brazil
Associação Paulista de Medicina - APM
2006
Associação Paulista de Medicina |
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| Abstract | Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson's disease diagnosis (sensitivity and specificity). |
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| AbstractList | Parkinson’s disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson’s disease diagnosis (sensitivity and specificity).
A doença de Parkinson (DP) é uma desordem neurodegenerativa causada por perda de neurônios dopaminérgicos na substância negra. Vários traçadores da medicina nuclear têm sido desenvolvidos para avaliar o diagnóstico e acompanhamento da DP. Traçadores para o transportador de dopamina (TDA) utilizados na tomografia por emissão de pósitrons (PET) e tomografia por emissão de fóton único (SPECT) demonstram boa marcação na integridade de sistema dopaminergico pré-sináptico, afetada na DP. Na última década, radiotraçadores apropriados para imagens de TDA têm sido mais estudados. Nesta revisão, provemos uma discussão crítica sobre a utilidade dessas imagens de TDA para o diagnóstico de DP (sensibilidade e especificidade). Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear medicine radiotracers have been developed to evaluate PD diagnoses and disease evolution in vivo in PD patients. Positron emission tomography (PET) and single photon computerized emission tomography (SPECT) radiotracers for the dopamine transporter (DAT) provide good markers for the integrity of the presynaptic dopaminergic system affected in PD. Over the last decade, radiotracers suitable for imaging the DAT have been the subject of most efforts. In this review, we provide a critical discussion on the utility of DAT imaging for Parkinson's disease diagnosis (sensitivity and specificity). |
| Author | Hoexter, Marcelo Queiroz Andrade, Luiz Augusto Franco de Bressan, Rodrigo Affonseca Shih, Ming Chi |
| AuthorAffiliation | Hospital Israelita Albert Einstein Universidade Federal de São Paulo |
| AuthorAffiliation_xml | – name: Hospital Israelita Albert Einstein – name: Universidade Federal de São Paulo |
| Author_xml | – sequence: 1 givenname: Ming Chi surname: Shih fullname: Shih, Ming Chi email: mingchi@psuquiatria.epm.br organization: Laboratório Interdisciplinar de Neuroimagem e Cognição, Universidade Federal de São Paulo, Rua Dr. Bacelar 334, CEP 04026-001 São Paulo, Brazil. mingchi@psuquiatria.epm.br – sequence: 2 givenname: Marcelo Queiroz surname: Hoexter fullname: Hoexter, Marcelo Queiroz – sequence: 3 givenname: Luiz Augusto Franco de surname: Andrade fullname: Andrade, Luiz Augusto Franco de – sequence: 4 givenname: Rodrigo Affonseca surname: Bressan fullname: Bressan, Rodrigo Affonseca |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17119698$$D View this record in MEDLINE/PubMed |
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| Keywords | Doença de Parkinson Dopamine Diagnóstico Dopamina Tomografia computadorizada de emissão Parkinson disease Emission-computed tomography Single-photon emission-computerized tomography Tomografia computadorizada de emissão de fóton único Diagnosis |
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| Snippet | Parkinson's disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear... Parkinson’s disease (PD) is a common neurodegenerative disorder that is mainly caused by dopaminergic neuron loss in the substantia nigra. Several nuclear... |
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| SubjectTerms | Diagnosis Dopamine Dopamine Agents Dopamine Plasma Membrane Transport Proteins Emission-computed tomography Humans MEDICINE, GENERAL & INTERNAL Organotechnetium Compounds Parkinson disease Parkinson Disease - diagnostic imaging Positron-Emission Tomography - standards Sensitivity and Specificity Single-photon emission-computerized tomography Tomography, Emission-Computed, Single-Photon - standards Tropanes |
| Title | Parkinson's disease and dopamine transporter neuroimaging: a critical review |
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