A peptidomimetic antagonist of TNF-alpha-mediated cytotoxicity identified from a phage-displayed random peptide library

Phage-displayed peptide libraries represent a vast collection of peptide sequences that can be used to identify novel therapeutic molecules. In this report, a 15-mer phage-displayed peptide library was used to identify potential TNF-alpha antagonists. After direct interaction of recombinant human TN...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 161; no. 10; pp. 5621 - 5626
Main Authors:	Chirinos-Rojas, C L, Steward, M W, Partidos, C D
Format:	Journal Article
Language:	English
Published:	United States 15-11-1998
Subjects:	Amino Acid Sequence Animals Bacteriophages - immunology Bacteriophages - isolation & purification Bacteriophages - metabolism Clone Cells Cytotoxicity, Immunologic - drug effects Humans Mice Molecular Mimicry Molecular Sequence Data Peptide Library Peptides - immunology Peptides - metabolism Peptides - pharmacology Protein Binding - immunology Recombinant Proteins - metabolism Sequence Analysis Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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