Structure and Function of Snake Venom Cardiotoxins

Structure and Function of Snake Venom Cardiotoxins

Cardiotoxins from elapid snake venoms are 'three-finger' shaped all β-sheet proteins with broad spectrum of biological properties. Members of this class possess strong membrane lytic property. Although, the amino acid sequences of cardiotoxins show more than 90% homology, the members of th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of toxicology. Toxin reviews Vol. 17; no. 2; pp. 183 - 211
Main Authors: Kumar, T.K.S., Pandian, S.K., Srisailam, S., Yu, C.
Format: Journal Article
Language:English
Published: Taylor & Francis 01-01-1998
Subjects:
Serpentes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiotoxins from elapid snake venoms are 'three-finger' shaped all β-sheet proteins with broad spectrum of biological properties. Members of this class possess strong membrane lytic property. Although, the amino acid sequences of cardiotoxins show more than 90% homology, the members of this class exhibit significant differences in erythrocyte lytic activity. Available evidence suggests that the 'active site' in cardiotoxins is constituted by non-polar and charged residues located in Loop 1 and Loop 2.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0731-3837
1525-6057
DOI:10.3109/15569549809009249