Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS)

Somatic mutations in are a hallmark of high-grade serous ovarian cancer (HGSOC), although their prognostic and predictive value as markers is not well defined. Next-generation sequencing (NGS) can identify novel mutations with high sensitivity, that may be repurposed as potential druggable anti-canc...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 19; no. 5; p. 1510
Main Authors:	Garziera, Marica, Cecchin, Erika, Canzonieri, Vincenzo, Sorio, Roberto, Giorda, Giorgio, Scalone, Simona, De Mattia, Elena, Roncato, Rossana, Gagno, Sara, Poletto, Elena, Romanato, Loredana, Sartor, Franca, Polesel, Jerry, Toffoli, Giuseppe
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 18-05-2018 MDPI
Subjects:	Aged Bioinformatics Case Report Female Frameshift Mutation Gene deletion Genetic markers Humans Immunohistochemistry INDEL Mutation Insertion Markers Middle Aged Mutation Neoplasms, Cystic, Mucinous, and Serous - genetics Neoplasms, Cystic, Mucinous, and Serous - pathology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology p53 Protein Patients Platinum Precision medicine Proteins Therapeutic applications Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors high-grade serous ovarian cancer (HGSOC) next-generation sequencing (NGS) TP53 gene mutations
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