Cystatin C promotes tau protein phosphorylation and causes microtubule instability by inhibiting intracellular turnover of GSK3β in neurons

In Alzheimer's disease (AD) tau protein hyperphosphorylation causes neurofibrillary tangle formation, microtubule instability and neurodegeneration. Determining the mechanism of tau hyperphosphorylation will provide a better understanding of AD pathology. Cystatin C (CysC) is a risk factor for...

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Bibliographic Details
Published in:	Molecular and cellular neuroscience Vol. 89; pp. 1 - 8
Main Authors:	Duan, Jinhai, Marcellus, Kristen A., Qin, Xike, Wang, Yunling, Paudel, Hemant K.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2018
Subjects:	3xTg-AD mice Alzheimer Disease - metabolism Alzheimer's disease Animals Cystatin C Cystatin C - pharmacology Glycogen Synthase Kinase 3 beta - metabolism GSK3β HEK293 Cells Humans Mice Microtubules - drug effects Microtubules - metabolism Neurons - drug effects Neurons - metabolism PC12 Cells Phosphorylation Protein Processing, Post-Translational Proteolysis Rats Tau phosphorylation tau Proteins - metabolism Tau phosphorylation Aβ GSK3β AD NFTs 3xTg-AD mice CysC Cystatin C Alzheimer's disease
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