Association of toll-like receptor 2 polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese
Mycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the ho...
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| Published in: | The Egyptian journal of medical human genetics Vol. 19; no. 3; pp. 261 - 265 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Cairo, Egypt
Elsevier B.V
01-07-2018
Egyptian Society of Human Genetics Springer Nature B.V SpringerOpen |
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| Abstract | Mycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the host response to MT. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. It has been proved that viable Mycobacterium bacilli contain distinct ligands that activate cells via TLR2.
This study was conducted to test the association of TLR2 gene polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese.
A case-control study of 207 Sudanese patients with pulmonary tuberculosis and 395 healthy controls was used. Three tag single nucleotide polymorphisms (SNPs) in TLR2 gene and its 3-Kb flanking regions on chromosome 4 were selected. The tag approach was set to r2 > 0.8 and minor allele frequency (MAF) > 0.2. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism method.
Genotypes of the 3 SNPs (rs1816702, rs3804099, and rs7656411) were estimated and compared. The stepwise regression procedure demonstrated that elimination of rs1816702 and rs3804099 from the model did not have any significant effect (p = .0685, .7300 respectively), while rs7656411 was significantly associated with tuberculosis susceptibility (p = .0372). TLR2 rs7656411 TG and GG genotypes frequencies were higher in pulmonary tuberculosis patients (OR = 1.74, 95% CI = 1.09–2.78, and OR = 2.24, 95% CI = 1.37–3.68 respectively). The haplotype TCG of TLR2 SNPs was also associated with TB susceptibility (p = .0004).
Our study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese. |
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| AbstractList | Background: Mycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the host response to MT. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. It has been proved that viable Mycobacterium bacilli contain distinct ligands that activate cells via TLR2. Aim: This study was conducted to test the association of TLR2 gene polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese. Subjects and methods: A case-control study of 207 Sudanese patients with pulmonary tuberculosis and 395 healthy controls was used. Three tag single nucleotide polymorphisms (SNPs) in TLR2 gene and its 3-Kb flanking regions on chromosome 4 were selected. The tag approach was set to r2 > 0.8 and minor allele frequency (MAF) > 0.2. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism method. Results: Genotypes of the 3 SNPs (rs1816702, rs3804099, and rs7656411) were estimated and compared. The stepwise regression procedure demonstrated that elimination of rs1816702 and rs3804099 from the model did not have any significant effect (p = .0685, .7300 respectively), while rs7656411 was significantly associated with tuberculosis susceptibility (p = .0372). TLR2 rs7656411 TG and GG genotypes frequencies were higher in pulmonary tuberculosis patients (OR = 1.74, 95% CI = 1.09–2.78, and OR = 2.24, 95% CI = 1.37–3.68 respectively). The haplotype TCG of TLR2 SNPs was also associated with TB susceptibility (p = .0004). Conclusion: Our study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese. Keywords: Toll-like receptor 2, Pulmonary tuberculosis, Polymorphisms BackgroundMycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the host response to MT. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. It has been proved that viable Mycobacterium bacilli contain distinct ligands that activate cells via TLR2.AimThis study was conducted to test the association of TLR2 gene polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese.Subjects and methodsA case-control study of 207 Sudanese patients with pulmonary tuberculosis and 395 healthy controls was used. Three tag single nucleotide polymorphisms (SNPs) in TLR2 gene and its 3-Kb flanking regions on chromosome 4 were selected. The tag approach was set to r2 > 0.8 and minor allele frequency (MAF) > 0.2. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism method.ResultsGenotypes of the 3 SNPs (rs1816702, rs3804099, and rs7656411) were estimated and compared. The stepwise regression procedure demonstrated that elimination of rs1816702 and rs3804099 from the model did not have any significant effect (p = .0685, .7300 respectively), while rs7656411 was significantly associated with tuberculosis susceptibility (p = .0372). TLR2 rs7656411 TG and GG genotypes frequencies were higher in pulmonary tuberculosis patients (OR = 1.74, 95% CI = 1.09–2.78, and OR = 2.24, 95% CI = 1.37–3.68 respectively). The haplotype TCG of TLR2 SNPs was also associated with TB susceptibility (p = .0004).ConclusionOur study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese. Background : Mycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the host response to MT. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. It has been proved that viable Mycobacterium bacilli contain distinct ligands that activate cells via TLR2. Aim: This study was conducted to test the association of TLR2 gene polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese. Subjects and methods: A case-control study of 207 Sudanese patients with pulmonary tuberculosis and 395 healthy controls was used. Three tag single nucleotide polymorphisms (SNPs) in TLR2 gene and its 3-Kb flanking regions on chromosome 4 were selected. The tag approach was set to r2 > 0.8 and minor allele frequency (MAF) > 0.2. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism method. Results: Genotypes of the 3 SNPs (rs1816702, rs3804099, and rs7656411) were estimated and compared. The stepwise regression procedure demonstrated that elimination of rs1816702 and rs3804099 from the model did not have any significant effect (p = .0685, .7300 respectively), while rs7656411 was significantly associated with tuberculosis susceptibility (p = .0372). TLR2 rs7656411 TG and GG genotypes frequencies were higher in pulmonary tuberculosis patients (OR = 1.74, 95% CI = 1.09–2.78, and OR = 2.24, 95% CI = 1.37–3.68 respectively). The haplotype TCG of TLR2 SNPs was also associated with TB susceptibility (p = .0004). Conclusion: Our study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese Mycobacterium tuberculosis (MT) is a leading cause of death worldwide, and the incidence of the tuberculosis) has been escalating due to the convergence of multidrug-resistant strains and HIV infection epidemics. Genetic and nongenetic factors of both the bacterium and the host have impact on the host response to MT. Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. It has been proved that viable Mycobacterium bacilli contain distinct ligands that activate cells via TLR2. This study was conducted to test the association of TLR2 gene polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese. A case-control study of 207 Sudanese patients with pulmonary tuberculosis and 395 healthy controls was used. Three tag single nucleotide polymorphisms (SNPs) in TLR2 gene and its 3-Kb flanking regions on chromosome 4 were selected. The tag approach was set to r2 > 0.8 and minor allele frequency (MAF) > 0.2. Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism method. Genotypes of the 3 SNPs (rs1816702, rs3804099, and rs7656411) were estimated and compared. The stepwise regression procedure demonstrated that elimination of rs1816702 and rs3804099 from the model did not have any significant effect (p = .0685, .7300 respectively), while rs7656411 was significantly associated with tuberculosis susceptibility (p = .0372). TLR2 rs7656411 TG and GG genotypes frequencies were higher in pulmonary tuberculosis patients (OR = 1.74, 95% CI = 1.09–2.78, and OR = 2.24, 95% CI = 1.37–3.68 respectively). The haplotype TCG of TLR2 SNPs was also associated with TB susceptibility (p = .0004). Our study suggests that allele G of rs765641 on TLR2 gene might influence susceptibility to pulmonary tuberculosis in Sudanese. |
| Author | Abdalla, B. Gasmelseed, N. Yip, S.P. Zaki, H. |
| Author_xml | – sequence: 1 givenname: H. surname: Zaki fullname: Zaki, H. email: hanizaki@uofg.edu.sd organization: Department of Biochemistry and Nutrition, Faculty of Medicine – University of Gezira, Sudan – sequence: 2 givenname: N. surname: Gasmelseed fullname: Gasmelseed, N. organization: Department of Molecular Biology – National Cancer Institute – University of Gezira, Sudan – sequence: 3 givenname: B. surname: Abdalla fullname: Abdalla, B. organization: Department of Biochemistry and Nutrition, Faculty of Medicine – University of Gezira, Sudan – sequence: 4 givenname: S.P. surname: Yip fullname: Yip, S.P. organization: Health Technology and Informatics Department – The Hong Kong Polytechnic University, Hong Kong |
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| CitedBy_id | crossref_primary_10_1016_j_cyto_2021_155791 crossref_primary_10_1016_j_arcmed_2022_04_006 crossref_primary_10_1016_j_cyto_2023_156405 |
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| Keywords | Polymorphisms Toll-like receptor 2 Pulmonary tuberculosis |
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| SubjectTerms | Age Alleles Bacilli Chromosome 4 Enzymes Ethics Gene frequency Gene polymorphism Genes Genotyping Haplotypes Immune response Innate immunity Kinases Multidrug resistance Polymerase chain reaction Polymorphisms Proteins Pulmonary tuberculosis Restriction fragment length polymorphism Single-nucleotide polymorphism Software Studies TLR2 protein Toll-like receptor 2 Toll-like receptors Tuberculosis |
| Title | Association of toll-like receptor 2 polymorphisms with susceptibility to pulmonary tuberculosis in Sudanese |
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