The role of cell therapies and hip arthroscopy in the management of osteonecrosis: an update

The role of cell therapies and hip arthroscopy in the management of osteonecrosis: an update

The exact pathophysiology of osteonecrosis of the femoral head (ONFH) is still unknown. There is evidence to suggest that in ON there is decreased population and altered function of the mesenchymal stem cells (MSCs) of the femoral head. This could influence both the actual occurrence of ON itself an...

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Bibliographic Details
Published in:Journal of hip preservation surgery Vol. 5; no. 3; pp. 202 - 208
Main Authors: Papavasiliou, Athanasios V, Triantafyllopoulos, Ioannis, Paxinos, Odysseas, Tsoukas, Dimitrios, Kostantoulakis, Charalambos
Format: Journal Article
Language:English
Published: England Oxford University Press 01-08-2018
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Review
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Summary:The exact pathophysiology of osteonecrosis of the femoral head (ONFH) is still unknown. There is evidence to suggest that in ON there is decreased population and altered function of the mesenchymal stem cells (MSCs) of the femoral head. This could influence both the actual occurrence of ON itself and the repair process that follows. Hence, in such an environment it only is rational to consider the use of cell-based treatments to potentially regenerate lost or damaged bone. The aim of this review is to provide an up-to-date, evidence-based information in the use of cell therapies in the treatment of nontraumatic ONFH and the use of hip arthroscopy in the field.
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ObjectType-Review-1
ISSN:2054-8397
2054-8397
DOI:10.1093/jhps/hny021