Methylenetetrahydrofolate reductase gene polymorphisms are associated with ischemic and hemorrhagic stroke: Dual effect of MTHFR polymorphisms C677T and A1298C

Hyperhomocysteinemia is an independent risk factor for ischemic stroke. The enzyme methylenetetrahydrofolate reductase (MTHFR) plays a critical role in modulating the levels of plasma homocysteine. Two polymorphisms in the MTHFR gene, C677T, A1298C result in reduced enzyme activity. The mechanisms o...

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Bibliographic Details
Published in:	Brain research bulletin Vol. 71; no. 1; pp. 45 - 50
Main Authors:	Sazci, Ali, Ergul, Emel, Tuncer, Nese, Akpinar, Gurler, Kara, Ihsan
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 11-12-2006
Subjects:	Adult Aged Aged, 80 and over Association Brain Ischemia - genetics Brain Ischemia - metabolism Brain Ischemia - physiopathology DNA Mutational Analysis European Continental Ancestry Group Female Gene Frequency Genetic Markers - genetics Genetic Predisposition to Disease - genetics Genetic Testing Genotype Hemorrhagic stroke Humans Intracranial Hemorrhages - genetics Intracranial Hemorrhages - metabolism Intracranial Hemorrhages - physiopathology Ischemic stroke Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged MTHFR Mutation - genetics Polymorphism Polymorphism, Genetic - genetics Stroke - genetics Stroke - metabolism Stroke - physiopathology Turkey Turkey MTHFR Association Turkey Ischemic stroke Hemorrhagic stroke Polymorphism
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