Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats

The pharmacokinetic behaviour of albendazole sulfoxide (ABZSO) enantiomers was studied in rats after the oral administration of 10 mg/kg of rac-ABZSO, 5 mg/kg of (−)-ABZSO or 5 mg/kg of (+)-ABZSO. The disposition profiles of ABZSO enantiomers were similar in all treatments, but the calculated area u...

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Bibliographic Details
Published in:	The veterinary journal (1997) Vol. 177; no. 2; pp. 297 - 299
Main Authors:	Capece, Bettencourt P.S., Castells, Gloria, Godoy, Carlo, Arboix, Margarita, Cristòfol, Carles
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2008
Subjects:	Administration, Oral albendazole Albendazole - administration & dosage Albendazole - analogs & derivatives Albendazole - blood Albendazole - chemistry Albendazole - pharmacokinetics Albendazole sulfoxide animal diseases animal models Animals Anthelmintics - administration & dosage Anthelmintics - blood Anthelmintics - chemistry Anthelmintics - pharmacokinetics dosage Dose-Response Relationship, Drug drug evaluation drug formulations drug therapy Enantiomers Enantioselectivity helminthiasis Isomerism metabolites oral administration Pharmacokinetics Rats veterinary drugs veterinary medicine Rats Enantioselectivity Enantiomers Pharmacokinetics Albendazole sulfoxide
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