Voltammetric oxidation and determination of loop diuretic furosemide at a multi-walled carbon nanotubes paste electrode

• Published in: Electrochimica acta Vol. 60; pp. 95 - 101
• Main Authors: Malode, Shweta J., Abbar, Jyothi C., Shetti, Nagaraj P., Nandibewoor, Sharanappa T.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 15-01-2012; Elsevier
• Subjects: Analysis; Anodic; Antihypertensive agents; Biological and medical sciences; Carbon; Cardiovascular system; Diuretics; Electrodes; Furosemide; General pharmacology; Medical sciences; Multi-wall carbon nanotubes; Nanomaterials; Nanostructure; Oxidation; Pastes; Pharmaceuticals; Pharmacology. Drug treatments; Urine; Voltammetry; Urine; Voltammetry; Furosemide; Multi-wall carbon nanotubes; Pharmaceuticals; Biological fluid; Carbon nanotubes; Paraffinic oil; Determination; Diuretic; pH; Tablet; Paste electrode; Oxidation; Electrochemical reaction; Modified material; Human; Sulfonamide; Oral form; Buffer solution; Multiwalled nanotube; Sulfonamides; Medium effect; Dosage form; Anthranilic acid derivatives; Antihypertensive agent
• ISSN: 0013-4686; 1873-3859
• DOI: 10.1016/j.electacta.2011.11.011

Multi-walled carbon nanotubes paste electrode has been successfully used for the oxidation of FUR in BR buffer solution (pH
=
5.0). Based on the study, influence of several physico-chemical parameters like potential scan rate, pH and concentration were investigated.
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► CNTPE has been successfully used for the electro-oxidation of FUR. ► Cyclic and differential-pulse voltammetric techniques are used. ► Effects of
E
pa,
I
pa and
k
0 have been discussed. ► DPV method was developed for the determination of FUR.
Electrochemical oxidation of loop diuretic furosemide (4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid) was studied in 5.0 pH with 0.04
M Britton–Robinson buffer as supporting electrolyte at 25
±
0.1
°C at a multi-walled carbon nanotubes-paraffin oil paste electrode (CNTPE) using cyclic and differential-pulse voltammetric (DPV) techniques. The electrochemical process was observed to be adsorption controlled, irreversible and involving two-electron oxidation. Effects of anodic peak potential (
E
pa), anodic peak current (
I
pa) and heterogeneous rate constant (
k
0) have been discussed. Under optimal conditions, the peak current was proportional to furosemide concentration in the range of 8.0
×
10
−6 to 2.0
×
10
−4
M with a detection limit of 2.9
×
10
−7
M by differential pulse voltammetry. A differential pulse voltammetric method with good precision and accuracy was developed for the determination of furosemide in pharmaceutical formulations and urine as a real sample.