Red Si-rhodamine drug conjugates enable imaging in GFP cells

Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.

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Bibliographic Details
Published in:	Chemical communications (Cambridge, England) Vol. 50; no. 34; p. 4504
Main Authors:	Kim, Eunha, Yang, Katherine S, Giedt, Randy J, Weissleder, Ralph
Format:	Journal Article
Language:	English
Published:	England 04-05-2014
Subjects:	Cell Line, Tumor Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Microscopy, Confocal Phthalazines - chemistry Piperazines - chemistry Rhodamines - chemistry Silicon - chemistry
Online Access:	Get more information
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Description
Summary:	Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.
ISSN:	1364-548X
DOI:	10.1039/c4cc00144c