Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin

We demonstrate a physiological role for tumstatin, a cleavage fragment of the α3 chain of type IV collagen (Col IVα3), which is present in the circulation. Mice with a genetic deletion of Col IVα3 show accelerated tumor growth associated with enhanced pathological angiogenesis, while angiogenesis as...

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Bibliographic Details

Published in:	Cancer cell Vol. 3; no. 6; pp. 589 - 601
Main Authors:	Hamano, Yuki, Zeisberg, Michael, Sugimoto, Hikaru, Lively, Julie C, Maeshima, Yohei, Yang, Changqing, Hynes, Richard O, Werb, Zena, Sudhakar, Akulapalli, Kalluri, Raghu
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 01-06-2003
Online Access:	Get full text
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