How much platelet-rich plasma can be soak-loaded onto beta-tricalcium phosphate? A comparison with or without a unidirectional porous structure

• Published in: Journal of Rural Medicine Vol. 16; no. 1; pp. 14 - 21
• Main Authors: Arai, Norihito, Yoshioka, Tomokazu, Sugaya, Hisashi, Kanamori, Akihiro, Yamazaki, Masashi
• Format: Journal Article
• Language: English
• Published: Japan THE JAPANESE ASSOCIATION OF RURAL MEDICINE 01-01-2021; The Japanese Association of Rural Medicine
• Subjects: artificial bone; loaded volume; Original; platelet-rich plasma; unidirectional porous; β-tricalcium phosphate; unidirectional porous; loaded volume; β-tricalcium phosphate; platelet-rich plasma; artificial bone
• ISSN: 1880-487X; 1880-4888
• DOI: 10.2185/jrm.2020-034

Objective: This study aimed to examine differences in platelet-rich plasma (PRP) soak-loaded volumes of β-tricalcium phosphate (β-TCP) with or without a unidirectional porous structure.Materials and Methods: Leukocyte-rich PRP was extracted from 15 healthy volunteers by centrifugation. Two types of artificial bones were soaked for either ten seconds or ten minutes. The volume ratios of PRP soak-loaded onto the artificial bone and soaked area ratios were evaluated. Statistical analyses were performed using the Tukey-Kramer HSD test and the Games-Howell method. A P-value of <0.05 was considered statistically significant.Results: Regardless of the soaking time, the PRP soak-loaded volume ratio and soaked area ratio were significantly higher in the unidirectional porous β-TCP (UDPTCP) group than in the spherical porous β-TCP (SPTCP) group.Conclusion: PRP can be soak-loaded faster and in larger amounts onto UDPTCP compared to SPTCP. Understanding the basic biology of β-TCP soak-loaded with PRP can help develop more novel and effective β-TCP treatments for orthopedic surgery.