Results of Animal Studies Suggest a Nonlinear Dose-Response Relationship for Benzene Effects

Considering the very large industrial usage of benzene, studies in risk assessment aimed at the evaluation of carcinogenic risk at low levels of exposure are important. Animal data can offer indications about what could happen in humans and provide more diverse information than epidemiological data...

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Bibliographic Details
Published in:	Environmental health perspectives Vol. 82; pp. 171 - 176
Main Authors:	Parodi, S., Lutz, W. K., Colacci, A., Mazzullo, M., Taningher, M., Grilli, S.
Format:	Journal Article
Language:	English
Published:	United States National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare 01-07-1989
Subjects:	560300 - Chemicals Metabolism & Toxicology Animals AROMATICS BENZENE Benzene - administration & dosage Benzene - metabolism Benzene - toxicity BIOLOGICAL EFFECTS CARCINOGENESIS Carcinogens DNA adducts Dosage Dose response relationship Dose-Response Relationship, Drug DOSE-RESPONSE RELATIONSHIPS EPIDEMIOLOGY HUMAN POPULATIONS HYDROCARBONS Implications of Animal Data to Human Risk Management Inhalation Leukemia Male Metabolism Mice Mutagens Oblateness ORGANIC COMPOUNDS PATHOGENESIS POPULATIONS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Rats Risk RISK ASSESSMENT Rodents
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