A population-based comparison of European and North American sinonasal cancer survival

• Published in: Auris, nasus, larynx Vol. 45; no. 4; pp. 815 - 824
• Main Authors: Unsal, Aykut A., Kılıç, Suat, Dubal, Pariket M., Baredes, Soly, Eloy, Jean Anderson
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-08-2018
• Subjects: Adenocarcinoma - epidemiology; Adenocarcinoma - mortality; Adolescent; Adult; Age Distribution; Age Factors; Aged; Carcinoma, Squamous Cell - epidemiology; Carcinoma, Squamous Cell - mortality; Databases, Factual; Europe; Europe - epidemiology; Europe, Eastern - epidemiology; Female; Head and Neck Neoplasms - epidemiology; Head and Neck Neoplasms - mortality; Humans; International; Ireland - epidemiology; Male; Middle Aged; North America - epidemiology; Nose Neoplasms - epidemiology; Nose Neoplasms - mortality; Paranasal Sinus Neoplasms - epidemiology; Paranasal Sinus Neoplasms - mortality; Population-based; Prognosis; Registries; Relative survival; SEER; SEER Program; Sex Distribution; Sex Factors; Sinonasal cancer; Squamous Cell Carcinoma of Head and Neck; Surveillance Epidemiology End Results; Survival; Survival Rate; United Kingdom - epidemiology; United States; United States - epidemiology; Young Adult; Europe, Eastern; United Kingdom; United States; North America; Europe; Ireland; Surveillance Epidemiology End Results; Population-based; Sinonasal cancer; Relative survival; United States; Europe; SEER; Survival; International
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/j.anl.2017.09.009

Sinonasal cancers (SNC) are rare, thus limiting previous prognostic studies on a multinational level. The aim of this study is to utilize two population-based datasets to compare prognoses for SNC between the United States (US) and Europe.
The European Cancer Registry (EUROCARE) database and the United States National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database were searched to identify survival of patients diagnosed with SNC between 1990 and 2007. Relative survival (RS) data were stratified by age group, gender, geographic location, and diagnostic time period.
12,541 SNC cases were identified in EUROCARE, while SEER identified 4,312. Males comprised the majority in Europe (62.3%) and the US (58.3%). Most patients were over 55 years in Europe (77.0%) and the US (69.5%). Age over 75 was a statistically significant poor prognostic indicator for 5-year RS in the US (48.2%; 95% CI=[43.9, 52.4]) and Europe (38.5%; [34.7, 42.7]). Female gender imparted a favorable 5-year RS in all regions except in Central Europe. By region, the US had the highest 5-year RS (58.8%; [56.4, 61.1]) and Eastern Europe had the lowest 5-year RS (37.1%; [34.0, 40.6]). The aggregate European 5-year RS was 48.1% [46.4, 49.8].
SNC in Europe and the US most commonly affects males and individuals over the age of 55 years. Male gender and age over 75 are poor prognostic factors at 5 years. Five-year RS in the US is higher than the 5-year European aggregate RS.