Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice

• Published in: The Journal of immunology (1950) Vol. 156; no. 3; pp. 1276 - 1283
• Main Authors: Nicholson, SM, Dal Canto, MC, Miller, SD, Melvold, RW
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01-02-1996
• Subjects: Animals; CD8-Positive T-Lymphocytes - radiation effects; CD8-Positive T-Lymphocytes - transplantation; Demyelinating Diseases - immunology; Demyelinating Diseases - prevention & control; Disease Susceptibility; Dose-Response Relationship, Radiation; Immune Tolerance - radiation effects; Immunity, Innate - radiation effects; Immunotherapy, Adoptive; Mice; Mice, Inbred BALB C; Poliomyelitis - immunology; Poliomyelitis - pathology; Poliomyelitis - prevention & control; Spleen - transplantation; Theilovirus - immunology
• ISSN: 0022-1767; 1550-6606
• DOI: 10.4049/jimmunol.156.3.1276

On intracerebral infection with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV), certain mouse strains develop a chronic demyelinating disease similar both clinically and pathologically to human multiple sclerosis. Other strains remain resistant. We previously established that differential susceptibility to this demyelinating disease exists among BALB/c substrains, with BALB/cAnNCr mice being susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice are rendered susceptible to TMEV-induced demyelination on exposure to low dose gamma-irradiation before TMEV infection. BALB/cAnNCr and irradiated, infected BALB/cByJ animals are protected against TMEV-induced demyelination by the transfer of a splenic population from TMEV-infected BALB/cByJ donors. Resistance to demyelination appears to be mediated by a CD8+ radiosensitive population, which is induced on infection with TMEV and which must act early to establish resistance to TMEV-induced demyelination.