Reduced natural killer activity in female mice after neonatal exposure to diethylstilbestrol

Treatment of neonatal female mice with DES markedly reduced the activity of NK cells in adult mice. This finding was most evident in C57BL/6 and BALB/c strains, but was also found in outbred NMRI mice. The mechanisms behind the reduced NK activity was further analyzed. No evidence of DES-induced cel...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 124; no. 3; pp. 1297 - 1300
Main Author:	Kalland, T
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-03-1980
Subjects:	Aging Animals Animals, Newborn Bone Marrow - immunology Cytotoxicity, Immunologic - drug effects Diethylstilbestrol - pharmacology Female Interferons - biosynthesis Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mitogens - pharmacology Ovary - drug effects Poly I-C - pharmacology Pregnancy Spleen - immunology
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Summary:	Treatment of neonatal female mice with DES markedly reduced the activity of NK cells in adult mice. This finding was most evident in C57BL/6 and BALB/c strains, but was also found in outbred NMRI mice. The mechanisms behind the reduced NK activity was further analyzed. No evidence of DES-induced cellular or humoral suppressors of natural killing could be detected. Pregnancy was found to be without effects on NK. Poly I:C augmented the NK activity in control females but even very high doses of Poly I:C failed to increase the level of NK activity in neonatally DES-treated animals. The lack of response to boosting with Poly I:C was not due to alterations in kinetics of NK induction.
ISSN:	0022-1767 1550-6606
DOI:	10.4049/jimmunol.124.3.1297