Expression of the Annexin A1 and its correlation with matrix metalloproteinases and the receptor for formylated peptide-2 in diffuse astrocytic tumors
Astrocytomas represent the majority of cerebral gliomas. Studies show that the anti-inflammatory protein Annexin-A1 (ANXA1) is associated with the tumor invasion process and that its actions can be mediated by the receptor for formylated peptides (FPR). Therefore, we evaluated the expression of ANXA...
Saved in:
| Published in: | Annals of diagnostic pathology Vol. 37; pp. 62 - 66 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
01-12-2018
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Astrocytomas represent the majority of cerebral gliomas. Studies show that the anti-inflammatory protein Annexin-A1 (ANXA1) is associated with the tumor invasion process and that its actions can be mediated by the receptor for formylated peptides (FPR). Therefore, we evaluated the expression of ANXA1, the receptor FPR2 and matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) in brain astrocytomas. Detection of proteins was performed in sections of diffuse astrocytomas (grade II), anaplastic astrocytomas (grade III) and glioblastomas (GBM, grade IV) and quantifications were made by densitometry. Our analyses showed increased expression of ANXA1 in astrocytomas of all grades, but especially in GBM. The expression of FPR2 is similar to that found for ANXA1, being higher in GBM. Immunostaining for MMPs is also stronger as the degree of malignancy increases, especially with respect to MMP-9. The positive correlation between ANXA1/FPR2 and ANXA1/MMP-9 was observed in all tumors studied. The data indicate the possible action of ANXA1 and FPR2 on the development and progression of astrocytomas, related to increased expression of MMP-9. Thereby, ANXA1 and FPR2 are involved in the biology and malignancy of diffuse astrocytic tumors.
•ANXA1, FPR2, MMP2 and MMP9 increase accordingly the malignant grade in diffuse astrocytic tumors.•ANXA1, FPR2, MMP2 and MMP9 are overexpressed in GBM.•ANXA1/FPR2 and ANXA1/MMP9 are positively correlated in diffuse astrocytic tumors grades II, III and IV.•ANXA1 is related to increased expression of MMPs in diffuse astrocytic tumors.•ANXA1 and FPR2 may be associated with malignancy phenotype in GBM. |
|---|---|
| AbstractList | Astrocytomas represent the majority of cerebral gliomas. Studies show that the anti-inflammatory protein Annexin-A1 (ANXA1) is associated with the tumor invasion process and that its actions can be mediated by the receptor for formylated peptides (FPR). Therefore, we evaluated the expression of ANXA1, the receptor FPR2 and matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) in brain astrocytomas. Detection of proteins was performed in sections of diffuse astrocytomas (grade II), anaplastic astrocytomas (grade III) and glioblastomas (GBM, grade IV) and quantifications were made by densitometry. Our analyses showed increased expression of ANXA1 in astrocytomas of all grades, but especially in GBM. The expression of FPR2 is similar to that found for ANXA1, being higher in GBM. Immunostaining for MMPs is also stronger as the degree of malignancy increases, especially with respect to MMP-9. The positive correlation between ANXA1/FPR2 and ANXA1/MMP-9 was observed in all tumors studied. The data indicate the possible action of ANXA1 and FPR2 on the development and progression of astrocytomas, related to increased expression of MMP-9. Thereby, ANXA1 and FPR2 are involved in the biology and malignancy of diffuse astrocytic tumors. Astrocytomas represent the majority of cerebral gliomas. Studies show that the anti-inflammatory protein Annexin-A1 (ANXA1) is associated with the tumor invasion process and that its actions can be mediated by the receptor for formylated peptides (FPR). Therefore, we evaluated the expression of ANXA1, the receptor FPR2 and matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) in brain astrocytomas. Detection of proteins was performed in sections of diffuse astrocytomas (grade II), anaplastic astrocytomas (grade III) and glioblastomas (GBM, grade IV) and quantifications were made by densitometry. Our analyses showed increased expression of ANXA1 in astrocytomas of all grades, but especially in GBM. The expression of FPR2 is similar to that found for ANXA1, being higher in GBM. Immunostaining for MMPs is also stronger as the degree of malignancy increases, especially with respect to MMP-9. The positive correlation between ANXA1/FPR2 and ANXA1/MMP-9 was observed in all tumors studied. The data indicate the possible action of ANXA1 and FPR2 on the development and progression of astrocytomas, related to increased expression of MMP-9. Thereby, ANXA1 and FPR2 are involved in the biology and malignancy of diffuse astrocytic tumors. •ANXA1, FPR2, MMP2 and MMP9 increase accordingly the malignant grade in diffuse astrocytic tumors.•ANXA1, FPR2, MMP2 and MMP9 are overexpressed in GBM.•ANXA1/FPR2 and ANXA1/MMP9 are positively correlated in diffuse astrocytic tumors grades II, III and IV.•ANXA1 is related to increased expression of MMPs in diffuse astrocytic tumors.•ANXA1 and FPR2 may be associated with malignancy phenotype in GBM. |
| Author | de Souza Costa, Sara Possebon, Lucas Iyomasa-Pilon, Melina Mizusaki Mayorquim, Matheus Vicente Geromel, Mairto Roberis Tadei, Maryam Buainain Souza, Helena Ribeiro de Souza, Camila Brambilla Girol, Ana Paula |
| Author_xml | – sequence: 1 givenname: Maryam Buainain surname: Tadei fullname: Tadei, Maryam Buainain organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 2 givenname: Matheus Vicente surname: Mayorquim fullname: Mayorquim, Matheus Vicente organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 3 givenname: Camila Brambilla surname: de Souza fullname: de Souza, Camila Brambilla organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 4 givenname: Sara surname: de Souza Costa fullname: de Souza Costa, Sara organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 5 givenname: Lucas surname: Possebon fullname: Possebon, Lucas organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 6 givenname: Helena Ribeiro surname: Souza fullname: Souza, Helena Ribeiro organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 7 givenname: Melina Mizusaki surname: Iyomasa-Pilon fullname: Iyomasa-Pilon, Melina Mizusaki organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 8 givenname: Mairto Roberis surname: Geromel fullname: Geromel, Mairto Roberis organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil – sequence: 9 givenname: Ana Paula surname: Girol fullname: Girol, Ana Paula email: anapaula.girol@fipa.com.br organization: University Center Padre Albino (UNIFIPA), Catanduva, SP, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30286327$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkc1u3CAUhVGVKH_NK1R0142ngDHg5WiUtJEiddOsEYHrDiMbXMDtzIvkect00qrLShdxhb5zjy7nGp2FGACh95SsKKHi425lQnDefJtN2a4YoWpFahH2Bl3RrmWNor06qz3pWdPTll-i65x3hFDKO3mBLlvClGiZvEIvd_s5Qc4-BhwHXLaA1yHA3ge8ptgEh33J2MaUYDTlSP30ZYsnU5Lf4wmKGcc4p1jAB5Mh_5YcpySwMJeY8HA606HqweG5vnoHDcPVwvlhWDJgk0uK9lC8xWWZYspv0flgxgy3r_cNerq_-7r53Dx--fSwWT82tpWyNKpTjnGhwBlOHLdMCnBWEsUl75zoQDBLhmfoHac9yA5aogiTppOOCytFe4M-nObWFb4vkIuefLYwjiZAXLJmlArF-07QivYn1KaYc4JBz8lPJh00JfoYi97pf2LRx1g0qUVY1b57tVmeJ3B_lX9yqMDmBEBd9oeHpLP1ECw4Xz-yaBf9f9j8AuxPqUM |
| CitedBy_id | crossref_primary_10_1016_j_expneurol_2019_112982 crossref_primary_10_1007_s10571_021_01134_y crossref_primary_10_1016_j_cca_2020_01_022 crossref_primary_10_1177_17590914211001218 crossref_primary_10_12677_ACM_2021_111011 crossref_primary_10_3389_fncel_2021_753832 crossref_primary_10_1098_rsob_230336 crossref_primary_10_1007_s10967_019_06500_1 crossref_primary_10_1515_oncologie_2024_0001 |
| Cites_doi | 10.1042/CS20150415 10.1158/0008-5472.CAN-07-0691 10.1111/j.1750-3639.2005.tb00118.x 10.1016/j.ajpath.2011.05.059 10.1038/onc.2008.122 10.18632/oncotarget.4725 10.1007/s00401-016-1545-1 10.1038/sj.bjc.6605591 10.1111/j.1471-4159.2007.04876.x 10.1007/s11060-016-2298-3 10.1097/NEN.0000000000000187 10.1038/modpathol.2009.132 10.1016/j.bbamcr.2014.07.008 10.1016/S0360-3016(01)02699-2 10.1016/j.cytogfr.2006.09.009 10.18632/oncotarget.19622 10.1371/journal.pone.0173417 10.1002/cncr.23338 10.1515/hsz-2016-0200 10.1007/s00403-014-1517-z 10.1093/jnci/dji142 10.1016/j.cellsig.2007.06.005 10.6004/jnccn.2018.0045 10.1371/journal.pone.0111317 10.1186/s12987-016-0043-0 10.4049/jimmunol.1001095 10.1371/journal.pone.0072376 10.1016/j.intimp.2012.07.015 10.1096/fj.14-263160 10.2217/fon.13.114 |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier Inc. Copyright © 2018 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier Inc. – notice: Copyright © 2018 Elsevier Inc. All rights reserved. |
| DBID | NPM AAYXX CITATION 7X8 |
| DOI | 10.1016/j.anndiagpath.2018.08.002 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1532-8198 |
| EndPage | 66 |
| ExternalDocumentID | 10_1016_j_anndiagpath_2018_08_002 30286327 S1092913417303635 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 1B1 1P~ 1~. 1~5 23M 4.4 457 4CK 4G. 53G 5GY 5VS 7-5 71M 8P~ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABBQC ABJNI ABLVK ABMAC ABMZM ABXDB ABYKQ ACDAQ ACGFS ACRLP ADBBV ADEZE ADMUD AEBSH AEKER AENEX AEVXI AFCTW AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG COF CS3 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-Q GBLVA HVGLF HZ~ IHE J1W KOM LCYCR M41 MO0 N9A O-L O9- OAUVE OG0 OS0 OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SDF SDG SEL SES SEW SPCBC SSH SSZ T5K UHS Z5R ~G- AAQOH AAXKI AFJKZ AKRWK NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c377t-858d2468eda40d4c276edc7084745d65e62c0fbe9d419e75e308027a57d46c763 |
| ISSN | 1092-9134 |
| IngestDate | Fri Oct 25 07:20:16 EDT 2024 Thu Sep 26 17:31:04 EDT 2024 Wed Oct 16 00:51:57 EDT 2024 Fri Feb 23 02:29:55 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | FPR Glioblastomas Astrocytomas Annexin A1 Metalloproteinases |
| Language | English |
| License | Copyright © 2018 Elsevier Inc. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c377t-858d2468eda40d4c276edc7084745d65e62c0fbe9d419e75e308027a57d46c763 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 30286327 |
| PQID | 2116849561 |
| PQPubID | 23479 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_2116849561 crossref_primary_10_1016_j_anndiagpath_2018_08_002 pubmed_primary_30286327 elsevier_sciencedirect_doi_10_1016_j_anndiagpath_2018_08_002 |
| PublicationCentury | 2000 |
| PublicationDate | December 2018 2018-Dec 2018-12-00 20181201 |
| PublicationDateYYYYMMDD | 2018-12-01 |
| PublicationDate_xml | – month: 12 year: 2018 text: December 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Annals of diagnostic pathology |
| PublicationTitleAlternate | Ann Diagn Pathol |
| PublicationYear | 2018 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | McArthur, Loiola, Maggioli, Errede, Virgintino, Solito (bb0070) 2016; 21; 13 Cheng, Tu, Zhang (bb0080) 2013; 26; 8 Souza, De Azevedo, Possebon, Costa, Iyomasa-Pilon, Oliani (bb0130) 2017; 12 McArthur, Cristante, Paterno, Christian, Roncaroli, Gillies (bb0065) 2010; 185 Kam, Liu, Wong (bb0110) 2007; 103 Smith, Gil, Oliani, Gavins (bb0075) 2015; 29 Ruano, Mollejo, Camacho, Rodríguez de Lope, Fiaño, Ribalta (bb0150) 2008; 112 Holdhoff (bb0015) 2018; 16 Bizzarro, Belvedere, Milone, Pucci, Lombardi, Bruzzese (bb0095) 2015; 6 Gobbetti, Cooray (bb0085) 2016; 397 Louis, Perry, Reifenberger, von Deimling, Figarella-Branger, Cavenee (bb0010) 2016; 131 Nager, Bhardwaj, Cantí, Medina, Nogués, Herreros (bb0005) 2012; 2012 Huang, Hu, Bian, Chen, Gong, Dunlop (bb0120) 2007; 67 Boudhraa, Merle, Mazzocut, Chezal, Chambon, Miot-Noirault (bb0100) 2014; 306 Mallawaaratchy, Hallal, Russell, Ly, Ebrahimkhani, Wei (bb0140) 2017; 131 Pagliara, Adornetto, Mammì, Masullo, Sarnataro, Pietropaolo (bb0035) 2014; 1843 Mallawaaratchy, Buckland, McDonald, Li, Ly, Sykes (bb0160) 2015; 74 Yang, Liu, Yao, Ping, Jiang, Liu (bb0145) 2011; 179 Lakka, Sgondi, Rao (bb0025) 2005; 15 Migeotte, Communi, Parmentier (bb0090) 2006; 17 Chen, Wei, Guan, Shu, Chen (bb0040) 2017; 27; 8 Liu, Zhao, Chen, Bian, Wang, Shi (bb0125) 2012; 14 Zhou, Bian, Le, Gong, Hu, Zhang (bb0165) 2005; 97 Muracciole, Romain, Dufour, Palmari, Chinot, Ouafik (bb0155) 2002; 52 Kam, Tse, Kwan, Wong (bb0105) 2007; 19 Kargiotis, Chetty, Gondi, Tsung, Dinh, Gujrati (bb0030) 2008; 27 Schittenhelm, Trautmann, Tabatabai, Hermann, Meyermann, Beschorner (bb0060) 2009; 22 Huang, Cristante, Paterno, Christian, Roncaroli, Gillies (bb0115) 2010; 102 Takaoka, Sertório, Magalini, Dos Santos, Souza, Iyomasa-Pilon (bb0135) 2017 Guo, Liu, Sun (bb0045) 2013; 9 Popescu, Purcaru, Alexandru, Dricu (bb0020) 2016; 20 Boudhraa, Bouchon, Viallard, D'Incan, Degoul (bb0055) 2016; 130 Gastardelo, Cunha, Raposo, Maniglia, Cury, Lisoni (bb0050) 2014; 9 Ruano (10.1016/j.anndiagpath.2018.08.002_bb0150) 2008; 112 Pagliara (10.1016/j.anndiagpath.2018.08.002_bb0035) 2014; 1843 Souza (10.1016/j.anndiagpath.2018.08.002_bb0130) 2017; 12 Gastardelo (10.1016/j.anndiagpath.2018.08.002_bb0050) 2014; 9 Liu (10.1016/j.anndiagpath.2018.08.002_bb0125) 2012; 14 Huang (10.1016/j.anndiagpath.2018.08.002_bb0115) 2010; 102 Takaoka (10.1016/j.anndiagpath.2018.08.002_bb0135) 2017 Guo (10.1016/j.anndiagpath.2018.08.002_bb0045) 2013; 9 Chen (10.1016/j.anndiagpath.2018.08.002_bb0040) 2017; 27; 8 Huang (10.1016/j.anndiagpath.2018.08.002_bb0120) 2007; 67 Lakka (10.1016/j.anndiagpath.2018.08.002_bb0025) 2005; 15 Zhou (10.1016/j.anndiagpath.2018.08.002_bb0165) 2005; 97 Boudhraa (10.1016/j.anndiagpath.2018.08.002_bb0100) 2014; 306 Migeotte (10.1016/j.anndiagpath.2018.08.002_bb0090) 2006; 17 Mallawaaratchy (10.1016/j.anndiagpath.2018.08.002_bb0140) 2017; 131 Muracciole (10.1016/j.anndiagpath.2018.08.002_bb0155) 2002; 52 Kam (10.1016/j.anndiagpath.2018.08.002_bb0105) 2007; 19 Louis (10.1016/j.anndiagpath.2018.08.002_bb0010) 2016; 131 Mallawaaratchy (10.1016/j.anndiagpath.2018.08.002_bb0160) 2015; 74 McArthur (10.1016/j.anndiagpath.2018.08.002_bb0065) 2010; 185 Nager (10.1016/j.anndiagpath.2018.08.002_bb0005) 2012; 2012 Holdhoff (10.1016/j.anndiagpath.2018.08.002_bb0015) 2018; 16 Gobbetti (10.1016/j.anndiagpath.2018.08.002_bb0085) 2016; 397 Kam (10.1016/j.anndiagpath.2018.08.002_bb0110) 2007; 103 Schittenhelm (10.1016/j.anndiagpath.2018.08.002_bb0060) 2009; 22 McArthur (10.1016/j.anndiagpath.2018.08.002_bb0070) 2016; 21; 13 Bizzarro (10.1016/j.anndiagpath.2018.08.002_bb0095) 2015; 6 Kargiotis (10.1016/j.anndiagpath.2018.08.002_bb0030) 2008; 27 Smith (10.1016/j.anndiagpath.2018.08.002_bb0075) 2015; 29 Cheng (10.1016/j.anndiagpath.2018.08.002_bb0080) 2013; 26; 8 Yang (10.1016/j.anndiagpath.2018.08.002_bb0145) 2011; 179 Popescu (10.1016/j.anndiagpath.2018.08.002_bb0020) 2016; 20 Boudhraa (10.1016/j.anndiagpath.2018.08.002_bb0055) 2016; 130 |
| References_xml | – year: 2017 ident: bb0135 article-title: Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias publication-title: Pathol Res Pract contributor: fullname: Iyomasa-Pilon – volume: 185 start-page: 6317 year: 2010 end-page: 6328 ident: bb0065 article-title: Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia publication-title: J Immunol contributor: fullname: Gillies – volume: 74 start-page: 425 year: 2015 end-page: 441 ident: bb0160 article-title: Membrane proteome analysis of glioblastoma cell invasion publication-title: J Neuropathol Exp Neurol contributor: fullname: Sykes – volume: 9 start-page: e111317 year: 2014 ident: bb0050 article-title: Inflammation and cancer: role of annexin A1 and FPR2/ALX in proliferation and metastasis in human laryngeal squamous cell carcinoma publication-title: PLoS One contributor: fullname: Lisoni – volume: 17 start-page: 501 year: 2006 end-page: 519 ident: bb0090 article-title: Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses publication-title: Cytokine Growth Factor Rev contributor: fullname: Parmentier – volume: 6 start-page: 25076 year: 2015 end-page: 25092 ident: bb0095 article-title: Annexin A1is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid publication-title: Oncotarget contributor: fullname: Bruzzese – volume: 21; 13 start-page: 17 year: 2016 ident: bb0070 article-title: The restorative role of annexin A1 at the blood-brain barrier publication-title: Fluids Barriers CNS contributor: fullname: Solito – volume: 14 start-page: 283 year: 2012 end-page: 288 ident: bb0125 article-title: G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma publication-title: Int Immunopharmacol contributor: fullname: Shi – volume: 130 start-page: 205 year: 2016 end-page: 220 ident: bb0055 article-title: Annexin A1 localization and its relevance to cancer publication-title: Clin Sci (Lond) contributor: fullname: Degoul – volume: 52 start-page: 592 year: 2002 end-page: 598 ident: bb0155 article-title: PAI-1 and EGFR expression in adult glioma tumors: toward a molecular prognostic classification publication-title: Int J Radiat Oncol Biol Phys contributor: fullname: Ouafik – volume: 16 start-page: 642 year: 2018 end-page: 645 ident: bb0015 article-title: Role of molecular pathology in the treatment of anaplastic gliomas and glioblastomas publication-title: J Natl Compr Canc Netw contributor: fullname: Holdhoff – volume: 9 start-page: 1773 year: 2013 end-page: 1793 ident: bb0045 article-title: Potential role of Anxa1 in cancer publication-title: Future Oncol contributor: fullname: Sun – volume: 306 start-page: 903 year: 2014 end-page: 914 ident: bb0100 article-title: Characterization of pro-invasive mechanisms and N-terminal cleavage of ANXA1 in melanoma publication-title: Arch Dermatol contributor: fullname: Miot-Noirault – volume: 20 start-page: 109 year: 2016 end-page: 118 ident: bb0020 article-title: New perspectives in glioblastoma antiangiogenic therapy publication-title: Contemp Oncol (Pozn) contributor: fullname: Dricu – volume: 26; 8 start-page: e72376 year: 2013 ident: bb0080 article-title: FoxM1 promotes glioma cells progression by up-regulating Anxa1 expression publication-title: PLoS One contributor: fullname: Zhang – volume: 67 start-page: 5906 year: 2007 end-page: 5913 ident: bb0120 article-title: Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells publication-title: Cancer Res contributor: fullname: Dunlop – volume: 15 start-page: 327 year: 2005 end-page: 341 ident: bb0025 article-title: Proteases and glioma angiogenesis publication-title: Brain Pathol contributor: fullname: Rao – volume: 2012 start-page: 192362 year: 2012 ident: bb0005 article-title: β-catenin signalling in glioblastoma multiforme and glioma-initiating cells publication-title: Chemother Res Pract contributor: fullname: Herreros – volume: 12 start-page: e0173417 year: 2017 ident: bb0130 article-title: Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment publication-title: PLoS One contributor: fullname: Oliani – volume: 131 start-page: 233 year: 2017 end-page: 244 ident: bb0140 article-title: Comprehensive proteome profiling of glioblastoma derived extracellular vesicles identifies markers for more aggressive disease publication-title: J Neurooncol contributor: fullname: Wei – volume: 22 start-page: 1600 year: 2009 end-page: 1611 ident: bb0060 article-title: Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival publication-title: Mod Pathol contributor: fullname: Beschorner – volume: 102 start-page: 1052 year: 2010 end-page: 1060 ident: bb0115 article-title: The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells publication-title: Br J Cancer contributor: fullname: Gillies – volume: 1843 start-page: 2631 year: 2014 end-page: 2644 ident: bb0035 article-title: Protease Nexin-1 affects the migration and invasion of C6 glioma cells through the regulation of urokinase Plasminogen Activator and Matrix Metalloproteinase-9/2 publication-title: Biochim Biophys Acta contributor: fullname: Pietropaolo – volume: 397 start-page: 981 year: 2016 end-page: 993 ident: bb0085 article-title: Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature publication-title: Biol Chem contributor: fullname: Cooray – volume: 19 start-page: 2106 year: 2007 end-page: 2117 ident: bb0105 article-title: Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin 1 alpha in human U87 astrocytoma cells publication-title: Cell Signal contributor: fullname: Wong – volume: 112 start-page: 1575 year: 2008 end-page: 1584 ident: bb0150 article-title: Identification of survival-related genes of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma multiforme publication-title: Cancer contributor: fullname: Ribalta – volume: 27; 8 start-page: 65969 year: 2017 end-page: 65982 ident: bb0040 article-title: EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism publication-title: Oncotarget contributor: fullname: Chen – volume: 29 start-page: 2161 year: 2015 end-page: 2171 ident: bb0075 article-title: Targeting formyl peptide receptor 2 reduces leukocyte-endothelial interactions in a murine model of stroke publication-title: FASEB J contributor: fullname: Gavins – volume: 103 start-page: 1553 year: 2007 end-page: 1566 ident: bb0110 article-title: Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-kappa B kinase in human U87 astrocytoma cells publication-title: J Neurochem contributor: fullname: Wong – volume: 27 start-page: 4830 year: 2008 end-page: 4840 ident: bb0030 article-title: Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma publication-title: Oncogene contributor: fullname: Gujrati – volume: 97 start-page: 823 year: 2005 end-page: 835 ident: bb0165 article-title: Formylpeptide receptor FPR and the rapid growth of malignant human gliomas publication-title: J Natl Cancer Inst contributor: fullname: Zhang – volume: 131 start-page: 803 year: 2016 end-page: 820 ident: bb0010 article-title: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary publication-title: Acta Neuropathol contributor: fullname: Cavenee – volume: 179 start-page: 1504 year: 2011 end-page: 1512 ident: bb0145 article-title: Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1 publication-title: Am J Pathol contributor: fullname: Liu – volume: 130 start-page: 205 year: 2016 ident: 10.1016/j.anndiagpath.2018.08.002_bb0055 article-title: Annexin A1 localization and its relevance to cancer publication-title: Clin Sci (Lond) doi: 10.1042/CS20150415 contributor: fullname: Boudhraa – volume: 67 start-page: 5906 issue: 12 year: 2007 ident: 10.1016/j.anndiagpath.2018.08.002_bb0120 article-title: Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0691 contributor: fullname: Huang – volume: 15 start-page: 327 issue: 4 year: 2005 ident: 10.1016/j.anndiagpath.2018.08.002_bb0025 article-title: Proteases and glioma angiogenesis publication-title: Brain Pathol doi: 10.1111/j.1750-3639.2005.tb00118.x contributor: fullname: Lakka – volume: 179 start-page: 1504 issue: 3 year: 2011 ident: 10.1016/j.anndiagpath.2018.08.002_bb0145 article-title: Annexin 1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl peptide receptor 1 publication-title: Am J Pathol doi: 10.1016/j.ajpath.2011.05.059 contributor: fullname: Yang – volume: 27 start-page: 4830 issue: 35 year: 2008 ident: 10.1016/j.anndiagpath.2018.08.002_bb0030 article-title: Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma publication-title: Oncogene doi: 10.1038/onc.2008.122 contributor: fullname: Kargiotis – volume: 6 start-page: 25076 issue: 28 year: 2015 ident: 10.1016/j.anndiagpath.2018.08.002_bb0095 article-title: Annexin A1is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid publication-title: Oncotarget doi: 10.18632/oncotarget.4725 contributor: fullname: Bizzarro – volume: 131 start-page: 803 year: 2016 ident: 10.1016/j.anndiagpath.2018.08.002_bb0010 article-title: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary publication-title: Acta Neuropathol doi: 10.1007/s00401-016-1545-1 contributor: fullname: Louis – volume: 102 start-page: 1052 issue: 6 year: 2010 ident: 10.1016/j.anndiagpath.2018.08.002_bb0115 article-title: The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells publication-title: Br J Cancer doi: 10.1038/sj.bjc.6605591 contributor: fullname: Huang – volume: 103 start-page: 1553 issue: 4 year: 2007 ident: 10.1016/j.anndiagpath.2018.08.002_bb0110 article-title: Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-kappa B kinase in human U87 astrocytoma cells publication-title: J Neurochem doi: 10.1111/j.1471-4159.2007.04876.x contributor: fullname: Kam – volume: 131 start-page: 233 issue: 2 year: 2017 ident: 10.1016/j.anndiagpath.2018.08.002_bb0140 article-title: Comprehensive proteome profiling of glioblastoma derived extracellular vesicles identifies markers for more aggressive disease publication-title: J Neurooncol doi: 10.1007/s11060-016-2298-3 contributor: fullname: Mallawaaratchy – volume: 74 start-page: 425 year: 2015 ident: 10.1016/j.anndiagpath.2018.08.002_bb0160 article-title: Membrane proteome analysis of glioblastoma cell invasion publication-title: J Neuropathol Exp Neurol doi: 10.1097/NEN.0000000000000187 contributor: fullname: Mallawaaratchy – volume: 22 start-page: 1600 issue: 12 year: 2009 ident: 10.1016/j.anndiagpath.2018.08.002_bb0060 article-title: Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival publication-title: Mod Pathol doi: 10.1038/modpathol.2009.132 contributor: fullname: Schittenhelm – volume: 1843 start-page: 2631 issue: 11 year: 2014 ident: 10.1016/j.anndiagpath.2018.08.002_bb0035 article-title: Protease Nexin-1 affects the migration and invasion of C6 glioma cells through the regulation of urokinase Plasminogen Activator and Matrix Metalloproteinase-9/2 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2014.07.008 contributor: fullname: Pagliara – year: 2017 ident: 10.1016/j.anndiagpath.2018.08.002_bb0135 article-title: Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias publication-title: Pathol Res Pract contributor: fullname: Takaoka – volume: 52 start-page: 592 issue: 3 year: 2002 ident: 10.1016/j.anndiagpath.2018.08.002_bb0155 article-title: PAI-1 and EGFR expression in adult glioma tumors: toward a molecular prognostic classification publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(01)02699-2 contributor: fullname: Muracciole – volume: 17 start-page: 501 issue: 6 year: 2006 ident: 10.1016/j.anndiagpath.2018.08.002_bb0090 article-title: Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses publication-title: Cytokine Growth Factor Rev doi: 10.1016/j.cytogfr.2006.09.009 contributor: fullname: Migeotte – volume: 27; 8 start-page: 65969 issue: 39 year: 2017 ident: 10.1016/j.anndiagpath.2018.08.002_bb0040 article-title: EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism publication-title: Oncotarget doi: 10.18632/oncotarget.19622 contributor: fullname: Chen – volume: 12 start-page: e0173417 issue: 3 year: 2017 ident: 10.1016/j.anndiagpath.2018.08.002_bb0130 article-title: Heterogeneity of mast cells and expression of Annexin A1 protein in a second degree burn model with silver sulfadiazine treatment publication-title: PLoS One doi: 10.1371/journal.pone.0173417 contributor: fullname: Souza – volume: 112 start-page: 1575 issue: 7 year: 2008 ident: 10.1016/j.anndiagpath.2018.08.002_bb0150 article-title: Identification of survival-related genes of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma multiforme publication-title: Cancer doi: 10.1002/cncr.23338 contributor: fullname: Ruano – volume: 20 start-page: 109 issue: 2 year: 2016 ident: 10.1016/j.anndiagpath.2018.08.002_bb0020 article-title: New perspectives in glioblastoma antiangiogenic therapy publication-title: Contemp Oncol (Pozn) contributor: fullname: Popescu – volume: 397 start-page: 981 year: 2016 ident: 10.1016/j.anndiagpath.2018.08.002_bb0085 article-title: Annexin A1 and resolution of inflammation: tissue repairing properties and signalling signature publication-title: Biol Chem doi: 10.1515/hsz-2016-0200 contributor: fullname: Gobbetti – volume: 306 start-page: 903 issue: 10 year: 2014 ident: 10.1016/j.anndiagpath.2018.08.002_bb0100 article-title: Characterization of pro-invasive mechanisms and N-terminal cleavage of ANXA1 in melanoma publication-title: Arch Dermatol doi: 10.1007/s00403-014-1517-z contributor: fullname: Boudhraa – volume: 97 start-page: 823 issue: 11 year: 2005 ident: 10.1016/j.anndiagpath.2018.08.002_bb0165 article-title: Formylpeptide receptor FPR and the rapid growth of malignant human gliomas publication-title: J Natl Cancer Inst doi: 10.1093/jnci/dji142 contributor: fullname: Zhou – volume: 2012 start-page: 192362 year: 2012 ident: 10.1016/j.anndiagpath.2018.08.002_bb0005 article-title: β-catenin signalling in glioblastoma multiforme and glioma-initiating cells publication-title: Chemother Res Pract contributor: fullname: Nager – volume: 19 start-page: 2106 issue: 10 year: 2007 ident: 10.1016/j.anndiagpath.2018.08.002_bb0105 article-title: Formyl peptide receptor like 1 differentially requires mitogen-activated protein kinases for the induction of glial fibrillary acidic protein and interleukin 1 alpha in human U87 astrocytoma cells publication-title: Cell Signal doi: 10.1016/j.cellsig.2007.06.005 contributor: fullname: Kam – volume: 16 start-page: 642 issue: 5S year: 2018 ident: 10.1016/j.anndiagpath.2018.08.002_bb0015 article-title: Role of molecular pathology in the treatment of anaplastic gliomas and glioblastomas publication-title: J Natl Compr Canc Netw doi: 10.6004/jnccn.2018.0045 contributor: fullname: Holdhoff – volume: 9 start-page: e111317 year: 2014 ident: 10.1016/j.anndiagpath.2018.08.002_bb0050 article-title: Inflammation and cancer: role of annexin A1 and FPR2/ALX in proliferation and metastasis in human laryngeal squamous cell carcinoma publication-title: PLoS One doi: 10.1371/journal.pone.0111317 contributor: fullname: Gastardelo – volume: 21; 13 start-page: 17 issue: 1 year: 2016 ident: 10.1016/j.anndiagpath.2018.08.002_bb0070 article-title: The restorative role of annexin A1 at the blood-brain barrier publication-title: Fluids Barriers CNS doi: 10.1186/s12987-016-0043-0 contributor: fullname: McArthur – volume: 185 start-page: 6317 issue: 10 year: 2010 ident: 10.1016/j.anndiagpath.2018.08.002_bb0065 article-title: Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia publication-title: J Immunol doi: 10.4049/jimmunol.1001095 contributor: fullname: McArthur – volume: 26; 8 start-page: e72376 issue: 8 year: 2013 ident: 10.1016/j.anndiagpath.2018.08.002_bb0080 article-title: FoxM1 promotes glioma cells progression by up-regulating Anxa1 expression publication-title: PLoS One doi: 10.1371/journal.pone.0072376 contributor: fullname: Cheng – volume: 14 start-page: 283 issue: 3 year: 2012 ident: 10.1016/j.anndiagpath.2018.08.002_bb0125 article-title: G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2012.07.015 contributor: fullname: Liu – volume: 29 start-page: 2161 issue: 5 year: 2015 ident: 10.1016/j.anndiagpath.2018.08.002_bb0075 article-title: Targeting formyl peptide receptor 2 reduces leukocyte-endothelial interactions in a murine model of stroke publication-title: FASEB J doi: 10.1096/fj.14-263160 contributor: fullname: Smith – volume: 9 start-page: 1773 year: 2013 ident: 10.1016/j.anndiagpath.2018.08.002_bb0045 article-title: Potential role of Anxa1 in cancer publication-title: Future Oncol doi: 10.2217/fon.13.114 contributor: fullname: Guo |
| SSID | ssj0011457 |
| Score | 2.2712862 |
| Snippet | Astrocytomas represent the majority of cerebral gliomas. Studies show that the anti-inflammatory protein Annexin-A1 (ANXA1) is associated with the tumor... |
| SourceID | proquest crossref pubmed elsevier |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 62 |
| SubjectTerms | Annexin A1 Astrocytomas FPR Glioblastomas Metalloproteinases |
| Title | Expression of the Annexin A1 and its correlation with matrix metalloproteinases and the receptor for formylated peptide-2 in diffuse astrocytic tumors |
| URI | https://dx.doi.org/10.1016/j.anndiagpath.2018.08.002 https://www.ncbi.nlm.nih.gov/pubmed/30286327 https://search.proquest.com/docview/2116849561 |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3da9swEBdpy8pextZ9ZV-osLfgYvlLNuwl2zK6QfaSbPTNyJYMLo2d1TE0_UP69-7Oku1kIdAx9hATFNsSul_uTtLv7gh5zz078-Eny1URt0D7KUskqWtFTiIw4ZUIEwwUPp_x7xfh54k3GQzaiqd923-VNLSBrDFy9i-k3b0UGuA7yByuIHW43kvukxtDbS3a4_9xgfkui9GYdScFKdbk0Cw4vRO7wEz9N1hPGg_im-QNeQEGruoYlqAZ1RIW6A0vET3dNTwP3uoSaTFSWU7Dq82zrK7USFQrMIxrTAa7qhelOTHaydksNc8Pb8PKyFs7_HMhVW6iidZiMfpYY5xX3mF5Ktbl9a9aF4Oeoh9bV6OfOZJNO6xKNZqV9a3QzJZFfiUAy2KRmEpLW_eAZjSeNG6Sb26GsPAPYkkXpbNFImV25DQMA23zWkUPloDpCtitJdDpZ4wqN0ZCOwW6MsyOudE7H5dnoihwxnCqkC0YnmmGbm9jO-bjDAeDY2EcnQfXPyBHDuhIUNFH46-Ti2_dERjzmjS13eCPyWlPTtzT4T7nat_iqXGi5o_JI7P6oWMN2ydkoIoT8kDXQ12fkOOpYXo8JXc9jmmZURAvNTimY0YBlBRwTDdwTBHHVOOY7uK4eQTf0uKYZvpjcEw7HFPowuCY9jimGsfPyI8vk_mnc8vUELFSl_OVFfqhdLwgVFJ4tvRShwdKptwGp8zzZeCrwEntLFGR9FikuK9cDD7nwufSC1Iwvs_JYVEW6iWhLOWwPogyFkjpCZYJKVyFse1BILmdREPitJMfL3WqmLjlUF7GGxKLUWIxVn-1nSH50IopNj6v9mVjwNh9Hj9tRRuDXcDDPlGosq5ih7EgxN0PNiQvtMy7UbmwqAhch7_6t85fk4f9f_ANOVxd1-otOahk_c6A-TdGTfKK |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Expression+of+the+Annexin+A1+and+its+correlation+with+matrix+metalloproteinases+and+the+receptor+for+formylated+peptide-2+in+diffuse+astrocytic+tumors&rft.jtitle=Annals+of+diagnostic+pathology&rft.au=Tadei%2C+Maryam+Buainain&rft.au=Mayorquim%2C+Matheus+Vicente&rft.au=de+Souza%2C+Camila+Brambilla&rft.au=de+Souza+Costa%2C+Sara&rft.date=2018-12-01&rft.pub=Elsevier+Inc&rft.issn=1092-9134&rft.eissn=1532-8198&rft.volume=37&rft.spage=62&rft.epage=66&rft_id=info:doi/10.1016%2Fj.anndiagpath.2018.08.002&rft.externalDocID=S1092913417303635 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1092-9134&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1092-9134&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1092-9134&client=summon |