Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs
This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at...
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| Published in: | Ciência rural Vol. 47; no. 9 |
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| Format: | Journal Article |
| Language: | English Portuguese |
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Santa Maria
Universidade Federal de Santa Maria Centro de Ciencias Rurais
2017
Universidade Federal de Santa Maria |
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| Abstract | This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at 8, 11, 14, 17, and 20h. Parameters were evaluated during baseline, treatment period of four days, and one day of post-treatment. During treatment phase, IOP decreased by 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), and 3.10mmHg (P<0.01), in dorzolamide/timolol-treated eyes; and by 1.50, 2.18, 2.14, and 2.18mmHg (P<0.001), in tafluprost-treated eyes. PD decreased by 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001), and 0.40mm (P<0.001), in dorzolamide/timolol treated eyes; and by 2.31, 2.55, 2.43, and 2.70mm (P<0.001), in tafluprost-treated eyes. Dorzolamide/timolol and tafluprost were able to decrease IOP and PD in healthy dogs. However, a cumulative effect of the fixed combination of dorzolamide/timolol was more effective in reducing IOP, than tafluprost. Comparisons between treatments showed that tafluprost was more effective in reducing PD throughout the treatment phase.
RESUMO: O estudo objetivou avaliar e comparar os efeitos da combinação fixa da dorzolamida/timolol com os da tafluprosta sobre a pressão intraocular (PIO) e o diâmetro pupilar (DP) em cães saudáveis (n=10). Dois experimentos com intervalo de 30 dias foram conduzidos. Em ambos, a PIO e o DP foram avaliados às 8, 11, 14, 17 e às 20h. Os parâmetros foram avaliados durante a fases basal, um período de tratamento de quatro dias, e um dia de pós-tratamento. Durante a fase de tratamento, a PIO dos olhos tratados com dorzolamida/timolol reduziram em 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), e 3.10mmHg (P<0.01); e dos olhos tratados com tafluprosta em 1.50, 2.18, 2.14 e 2.18mmHg (P<0.001). O DP dos olhos tratados com dorzolamida/timolol reduziram em 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001) e 0.40mm (P<0.001); e dos olhos tratados com tafluprosta em 2.31, 2.55, 2.43 e 2.70mm (P<0.001). A dorzolamida/timol e a tafluprosta foram capazes de reduzir a PIO e o DP em cães saudáveis. Porém, efeito cumulativo do tratamento com dorzolamida/timolol foi observado, decorridos três dias de tratamento. Por essa razão, a dorzolamida/timolol foi mais efetiva que a tafluprosta na redução da PIO. Comparações entre os tratamentos demonstraram que a tafluprosta foi mais efetiva em reduzir o DP, durante toda a fase de tratamento. |
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| AbstractList | This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at 8, 11, 14, 17, and 20h. Parameters were evaluated during baseline, treatment period of four days, and one day of post-treatment. During treatment phase, IOP decreased by 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), and 3.10mmHg (P<0.01), in dorzolamide/timolol-treated eyes; and by 1.50, 2.18, 2.14, and 2.18mmHg (P<0.001), in tafluprost-treated eyes. PD decreased by 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001), and 0.40mm (P<0.001), in dorzolamide/timolol treated eyes; and by 2.31, 2.55, 2.43, and 2.70mm (P<0.001), in tafluprost-treated eyes. Dorzolamide/timolol and tafluprost were able to decrease IOP and PD in healthy dogs. However, a cumulative effect of the fixed combination of dorzolamide/timolol was more effective in reducing IOP, than tafluprost. Comparisons between treatments showed that tafluprost was more effective in reducing PD throughout the treatment phase. This study aimed to evaluate and compare the effects of the fixed combination of dorzolamide/timolol with those of tafluprost on intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs (n=10). Two experiments were conducted with an interval of 30 days. In both, IOP and PD were assessed at 8, 11, 14, 17, and 20h. Parameters were evaluated during baseline, treatment period of four days, and one day of post-treatment. During treatment phase, IOP decreased by 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), and 3.10mmHg (P<0.01), in dorzolamide/timolol-treated eyes; and by 1.50, 2.18, 2.14, and 2.18mmHg (P<0.001), in tafluprost-treated eyes. PD decreased by 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001), and 0.40mm (P<0.001), in dorzolamide/timolol treated eyes; and by 2.31, 2.55, 2.43, and 2.70mm (P<0.001), in tafluprost-treated eyes. Dorzolamide/timolol and tafluprost were able to decrease IOP and PD in healthy dogs. However, a cumulative effect of the fixed combination of dorzolamide/timolol was more effective in reducing IOP, than tafluprost. Comparisons between treatments showed that tafluprost was more effective in reducing PD throughout the treatment phase. RESUMO: O estudo objetivou avaliar e comparar os efeitos da combinação fixa da dorzolamida/timolol com os da tafluprosta sobre a pressão intraocular (PIO) e o diâmetro pupilar (DP) em cães saudáveis (n=10). Dois experimentos com intervalo de 30 dias foram conduzidos. Em ambos, a PIO e o DP foram avaliados às 8, 11, 14, 17 e às 20h. Os parâmetros foram avaliados durante a fases basal, um período de tratamento de quatro dias, e um dia de pós-tratamento. Durante a fase de tratamento, a PIO dos olhos tratados com dorzolamida/timolol reduziram em 0.74 (P<0.05), 1.88 (P<0.01), 2.94 (P<0.001), e 3.10mmHg (P<0.01); e dos olhos tratados com tafluprosta em 1.50, 2.18, 2.14 e 2.18mmHg (P<0.001). O DP dos olhos tratados com dorzolamida/timolol reduziram em 0.24 (P<0.01), 0.32 (P<0.01), 0.49 (P<0.001) e 0.40mm (P<0.001); e dos olhos tratados com tafluprosta em 2.31, 2.55, 2.43 e 2.70mm (P<0.001). A dorzolamida/timol e a tafluprosta foram capazes de reduzir a PIO e o DP em cães saudáveis. Porém, efeito cumulativo do tratamento com dorzolamida/timolol foi observado, decorridos três dias de tratamento. Por essa razão, a dorzolamida/timolol foi mais efetiva que a tafluprosta na redução da PIO. Comparações entre os tratamentos demonstraram que a tafluprosta foi mais efetiva em reduzir o DP, durante toda a fase de tratamento. |
| Author | Maciel, Camila do Espirito Santo Dower, Nathalie Moro Bassil Spiller, Paulo Roberto Pizzinatto, Fábio Dumit Ribeiro, Alexandre Pinto Monteiro, Geovanna Barreira Yamauchi, Kelly Cristiane Ito |
| AuthorAffiliation | Universidade Federal de Mato Grosso Universidade de Cuiabá |
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| Author_xml | – sequence: 1 givenname: Nathalie Moro Bassil surname: Dower fullname: Dower, Nathalie Moro Bassil organization: Universidade Federal de Mato Grosso, Brazil – sequence: 2 givenname: Alexandre Pinto surname: Ribeiro fullname: Ribeiro, Alexandre Pinto organization: Universidade Federal de Mato Grosso, Brazil – sequence: 3 givenname: Camila do Espirito Santo surname: Maciel fullname: Maciel, Camila do Espirito Santo organization: Universidade Federal de Mato Grosso, Brazil – sequence: 4 givenname: Paulo Roberto surname: Spiller fullname: Spiller, Paulo Roberto organization: Universidade Federal de Mato Grosso, Brazil – sequence: 5 givenname: Geovanna Barreira surname: Monteiro fullname: Monteiro, Geovanna Barreira organization: Universidade Federal de Mato Grosso, Brazil – sequence: 6 givenname: Fábio Dumit surname: Pizzinatto fullname: Pizzinatto, Fábio Dumit organization: Universidade Federal de Mato Grosso, Brazil – sequence: 7 givenname: Kelly Cristiane Ito surname: Yamauchi fullname: Yamauchi, Kelly Cristiane Ito organization: Universidade de Cuiabá, Brazil |
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| Keywords | prostaglandin analogs beta bloqueador análogos da prostaglandina beta blocker glaucoma carbonic anhydrase inhibitor dogs inibidores da anidrase carbônica cães |
| Language | English Portuguese |
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| References | CAWRSE M.A. (ref2) 2001; 62 GELATT K.N. (ref4) 2001; 4 SEO D.R. (ref12) 2015 OTA T. (ref8) 2005; 46 PLUMMER C.E. (ref10) 2006; 9 KWAK J. (ref7) 2017; 20 PIZZIRANI S. (ref9) 2015; 45 SMITH L.N. (ref13) 2010; 71 FOGAGNOLO P. (ref3) 2015; 32 GIANNICO A.T. (ref5) 2016; 79 JOHNSTONE MCLEAN N.S. (ref6) 2008; 11 TAKIYAMA N. (ref14) 2009 PLUMMER C.E. (ref11) 2013 BORGES A.G. (ref1) 2007; 59 TAKIYAMA, N. 2009 2015; 45 2017; 20 2001; 4 2006; 9 2015; 32 2008; 11 2015 PLUMMER, C.E.; GELATT, K.N. 2013 2001; 62 2016; 79 2007; 59 2005; 46 2010; 71 |
| References_xml | – volume: 59 start-page: .660 issue: 3 year: 2007 ident: ref1 article-title: Efficacy of timolol maleate 0.5% dorzolamide hydrochloride 2%, and the combination of both drugs on intraocular pressure publication-title: Arquivos Brasileiros de Medicina Veterináriae Zootecnia contributor: fullname: BORGES A.G. – volume: 79 start-page: 33 issue: 1 year: 2016 ident: ref5 article-title: Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits. publication-title: Arquivos Brasileiros de Oftalmologia doi: 10.5935/0004-2749.20160010 contributor: fullname: GIANNICO A.T. – start-page: 1050 volume-title: The canine glaucomas year: 2013 ident: ref11 contributor: fullname: PLUMMER C.E. – volume: 46 start-page: 2006 issue: 6 year: 2005 ident: ref8 article-title: Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation publication-title: Investigative Ophthalmology and Visual Science doi: 10.1167/iovs.04-1527 contributor: fullname: OTA T. – volume: 20 start-page: 34 issue: 1 year: 2017 ident: ref7 article-title: Effect of preservative-free tafluprost on intraocular pressure, pupil diameter, and anterior segment structures in normal canine eyes. publication-title: Veterinary Ophthalmology doi: 10.1111/vop.12341 contributor: fullname: KWAK J. – volume: 11 start-page: 158 issue: 3 year: 2008 ident: ref6 article-title: The effect of a single dose of topical 0.005% latanoprost and 2% dorzolamide/0.5% timolol combination on the blood-aqueous barrier in dogs: a pilot study publication-title: Veterinary Ophthalmology doi: 10.1111/j.1463-5224.2008.00609.x contributor: fullname: JOHNSTONE MCLEAN N.S. – start-page: 390 year: 2009 ident: ref14 contributor: fullname: TAKIYAMA N. – volume: 4 start-page: 61 issue: 1 year: 2001 ident: ref4 article-title: Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. publication-title: Veterinary Ophthalmology doi: 10.1046/j.1463-5224.2001.00141.x contributor: fullname: GELATT K.N. – year: 2015 ident: ref12 article-title: Comparison of ocular pulse amplitude lowering effects of preservative-free tafluprost and preservative-free dorzolamide-timolol fixed combination eyedrops publication-title: BioMed Research International contributor: fullname: SEO D.R. – volume: 32 start-page: 356 issue: 4 year: 2015 ident: ref3 article-title: A 1-year randomized study of the clinical and confocal effects of tafluprost and latanoprost in newly diagnosed glaucoma patients publication-title: Advances in Therapy doi: 10.1007/s12325-015-0205-5 contributor: fullname: FOGAGNOLO P. – volume: 9 start-page: 245 issue: 4 year: 2006 ident: ref10 article-title: Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs. publication-title: Veterinary Ophthalmology doi: 10.1111/j.1463-5224.2006.00469.x contributor: fullname: PLUMMER C.E. – volume: 71 start-page: 1055 issue: 9 year: 2010 ident: ref13 article-title: Effects of topical administration of latanoprost, timolol, or a combination of latanoprost and timolol on intraocular pressure, pupil size, and heart rate in clinically normal dogs publication-title: American Journal of Veterinary Research doi: 10.2460/ajvr.71.9.1055 contributor: fullname: SMITH L.N. – volume: 45 start-page: 1127 issue: 6 year: 2015 ident: ref9 article-title: Definition, classification, and pathophysiology of canine glaucoma publication-title: Veterinary Clinics of North America: Small Animal Practice doi: 10.1016/j.cvsm.2015.06.002 contributor: fullname: PIZZIRANI S. – volume: 62 start-page: 859 issue: 6 year: 2001 ident: ref2 article-title: Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs publication-title: American Journal of Veterinary Research doi: 10.2460/ajvr.2001.62.859 contributor: fullname: CAWRSE M.A. – volume: 45 start-page: 1127 issue: 6 year: 2015 end-page: 1157 article-title: Definition, classification, and pathophysiology of canine glaucoma publication-title: Veterinary Clinics of North America: Small Animal Practice – start-page: 1050 year: 2013 end-page: 1145 publication-title: Veterinary ophthalmology contributor: fullname: PLUMMER, C.E.; GELATT, K.N. – volume: 11 start-page: 158 issue: 3 year: 2008 end-page: 151 article-title: The effect of a single dose of topical 0.005% latanoprost and 2% dorzolamide/0.5% timolol combination on the blood-aqueous barrier in dogs: a pilot study publication-title: Veterinary Ophthalmology – volume: 59 start-page: .660 issue: 3 year: 2007 end-page: .664 article-title: Efficacy of timolol maleate 0.5% dorzolamide hydrochloride 2%, and the combination of both drugs on intraocular pressure publication-title: Arquivos Brasileiros de Medicina Veterináriae Zootecnia – volume: 4 start-page: 61 issue: 1 year: 2001 end-page: 67 article-title: Changes in intraocular pressure associated with topical dorzolamide and oral methazolamide in glaucomatous dogs. publication-title: Veterinary Ophthalmology – year: 2015 article-title: Comparison of ocular pulse amplitude lowering effects of preservative-free tafluprost and preservative-free dorzolamide-timolol fixed combination eyedrops publication-title: BioMed Research International – volume: 32 start-page: 356 issue: 4 year: 2015 end-page: 369 article-title: A 1-year randomized study of the clinical and confocal effects of tafluprost and latanoprost in newly diagnosed glaucoma patients publication-title: Advances in Therapy – volume: 46 start-page: 2006 issue: 6 year: 2005 end-page: 2011 article-title: Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation publication-title: Investigative Ophthalmology and Visual Science – volume: 20 start-page: 34 issue: 1 year: 2017 end-page: 39 article-title: Effect of preservative-free tafluprost on intraocular pressure, pupil diameter, and anterior segment structures in normal canine eyes. publication-title: Veterinary Ophthalmology – start-page: 390 year: 2009 end-page: 409 publication-title: Effects of tafluprost 0.0015% compared with latanoprost 0.005% on the IOP and pupil size of normotensive dogs contributor: fullname: TAKIYAMA, N. – volume: 71 start-page: 1055 issue: 9 year: 2010 end-page: 1061 article-title: Effects of topical administration of latanoprost, timolol, or a combination of latanoprost and timolol on intraocular pressure, pupil size, and heart rate in clinically normal dogs publication-title: American Journal of Veterinary Research – volume: 9 start-page: 245 issue: 4 year: 2006 end-page: 249 article-title: Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs. publication-title: Veterinary Ophthalmology – volume: 79 start-page: 33 issue: 1 year: 2016 end-page: 36 article-title: Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits. publication-title: Arquivos Brasileiros de Oftalmologia – volume: 62 start-page: 859 issue: 6 year: 2001 end-page: 863 article-title: Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs publication-title: American Journal of Veterinary Research |
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| SubjectTerms | AGRONOMY beta blocker carbonic anhydrase inhibitor Dogs Drugs Evaluation Glaucoma Intraocular pressure prostaglandin analogs Timolol |
| Title | Effects of dorzolamide/timolol and tafluprost on intraocular pressure and pupil diameter in healthy dogs |
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