Permeability change and brain tissue damage after intracarotid administration of cisplatin studied by double-tracer autoradiography in rats

The present study was designed to find the reliable parameter(s) for the detection of early neurotoxicity following intracarotid (IC) administration of cisplatin. IC administration was performed for 60 minutes in female Wistar rats derived into four groups according to the dose given (1 mg, 1.2 mg,...

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Bibliographic Details
Published in:	Journal of neuro-oncology Vol. 24; no. 3; pp. 229 - 240
Main Authors:	SUGIMOTO, S, YAMAMOTO, Y. L, NAGAHIRO, S, DIKSIC, M
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer 01-01-1995
Subjects:	Animals Antineoplastic Agents - toxicity Autoradiography - methods Biological and medical sciences Blood-Brain Barrier - drug effects Brain - drug effects Carbon Radioisotopes Carotid Arteries Cerebrovascular Circulation - drug effects Cisplatin - toxicity Drug toxicity and drugs side effects treatment Female Fluorine Radioisotopes Injections, Intra-Arterial Medical sciences Microcirculation - drug effects Pharmacology. Drug treatments Rats Rats, Wistar Toxicity: nervous system and muscle Intracranial Nervous system diseases Cell permeability Rat Toxicity Rodentia Malignant tumor Blood brain barrier Cerebral disorder Vertebrata Chemotherapy Mammalia Treatment Analysis Animal Carotid Central nervous system disease Tumor Intraarterial administration
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