The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine

• Published in: European journal of drug metabolism and pharmacokinetics Vol. 16; no. 3; pp. 177 - 181
• Main Authors: KOPITAR, Z, VRHOVAC, B, LOVSIC, L, PLAVSIC, F, FRANCETIC, I, URBANCIC, J
• Format: Journal Article
• Language: English
• Published: Genève Médecine et hygiène 01-07-1991
• Subjects: Administration, Oral; Adult; Biological and medical sciences; Biological Availability; Bromocriptine - administration & dosage; Bromocriptine - adverse effects; Bromocriptine - blood; Bromocriptine - pharmacokinetics; Catecholaminergic system; Food; Humans; Male; Medical sciences; Metoclopramide - pharmacology; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Radioimmunoassay; Bromocryptine; Human; Dopamine agonist; Oral administration; Drug interaction; Normal; Pharmacokinetics; Antiparkinson agent; Food drug interaction
• ISSN: 0378-7966; 2107-0180
• DOI: 10.1007/bf03189956

The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slightly lower when the drug was given after breakfast. Bioavailability of the drug was not significantly reduced by food nor by metoclopramide pre-treatment. Side effects of bromocriptine were considerably reduced by metoclopramide pre-treatment (0.5 mg/kg); the decrease was about 83% as estimated from Table II.