Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy

Cisplatin induces DNA crosslinks that are highly cytotoxic. Hence, platinum complexes are frequently used in the treatment of a broad range of cancers. Efficiency of cisplatin treatment is limited by the tumor-specific DNA damage response to the generated lesions. We reasoned that better tools to in...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 12; p. 874201
Main Authors:	Moretton, Amandine, Slyskova, Jana, Simaan, Marwan E, Arasa-Verge, Emili A, Meyenberg, Mathilde, Cerrón-Infantes, D Alonso, Unterlass, Miriam M, Loizou, Joanna I
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 02-06-2022
Subjects:	chemoresistance chemotherapy cisplatin DNA crosslinks DNA Damage DNA repair Oncology chemoresistance DNA crosslinks click chemistry DNA Damage cisplatin DNA repair chemotherapy
Online Access:	Get full text
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