The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of beta-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.

Bibliographic Details

Published in:	Nature structural biology Vol. 3; no. 9; pp. 747 - 752
Main Authors:	Hrabal, Richard, Chen, Zhigang, James, Susan, Bennett, Hugh P.J, Ni, Feng
Format:	Journal Article
Language:	English
Published:	United States 01-09-1996
Subjects:	Amino Acid Sequence Animals Carps Intercellular Signaling Peptides and Proteins Magnetic Resonance Spectroscopy Molecular Sequence Data Protein Structure, Secondary Proteins - chemistry
Online Access:	Get full text
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