Thyroid Hormone Deficiency Suppresses Fetal Pituitary-Adrenal Function Near Term: Implications for the Control of Fetal Maturation and Parturition

The fetal hypothalamic-pituitary-adrenal (HPA) axis plays a key role in the control of parturition and maturation of organ systems in preparation for birth. In hypothyroid fetuses, gestational length may be prolonged and maturational processes delayed. The extent to which the effects of thyroid horm...

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Bibliographic Details
Published in:	Thyroid (New York, N.Y.) Vol. 31; no. 6; p. 861
Main Authors:	Camm, Emily J, Inzani, Isabella, De Blasio, Miles J, Davies, Katie L, Lloyd, India R, Wooding, F B Peter, Blache, Dominique, Fowden, Abigail L, Forhead, Alison J
Format:	Journal Article
Language:	English
Published:	United States 01-06-2021
Subjects:	Adrenal Cortex Hormones - metabolism Adrenal Glands - metabolism Adrenal Glands - pathology Adrenal Medulla - metabolism Adrenal Medulla - pathology Adrenocorticotropic Hormone - metabolism Animals Cell Count Cell Proliferation Congenital Hypothyroidism - metabolism Congenital Hypothyroidism - pathology Corticotrophs - metabolism Corticotrophs - pathology Fetal Development - physiology Fetal Diseases - metabolism Fetal Diseases - pathology Fetal Organ Maturity Hydrocortisone - blood Hypothalamo-Hypophyseal System - metabolism Insulin-Like Growth Factor I - genetics Pituitary-Adrenal System - metabolism Receptor, IGF Type 1 - genetics RNA, Messenger - metabolism Sheep Thyroidectomy Thyroxine - deficiency Thyroxine - metabolism Triiodothyronine - deficiency Triiodothyronine - metabolism Zona Fasciculata - metabolism Zona Fasciculata - pathology cortisol corticotrophs thyroid hormones ACTH adrenal gland pituitary gland fetus
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