Sex differences in the impact of coexistent diabetes on survival in patients with coronary heart disease
To evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease
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| Published in: | Diabetes care Vol. 16; no. 5; pp. 708 - 713 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Alexandria, VA
American Diabetes Association
01-05-1993
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| Abstract | To evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease |
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| AbstractList | Sex differences in the impact of coexistent diabetes on survival in patients with coronary heart disease.
Y Liao ,
R S Cooper ,
J K Ghali ,
D Lansky ,
G Cao and
J Lee
Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, Illinois 60153.
Abstract
OBJECTIVE--To evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease. RESEARCH
DESIGN AND METHODS--Cohort study based on a sample from a hospital registry in Chicago, IL. A total of 974 consecutive patients
(585 men and 389 women) with angiographically confirmed coronary artery disease were followed for 4.6 yr. RESULTS--At baseline,
160 men and 155 women had diabetes. The age-adjusted relative risk of death from all causes for patients with diabetes versus
patients without diabetes was 0.93 (95% confidence interval 0.65-1.34) in men and 1.99 (95% CI 1.30-3.05) in women. For cardiac
death, the corresponding relative risk was 1.00 (95% CI 0.64-1.56) and 1.96 (95% CI 1.19-3.24) in men and women, respectively.
Baseline differences in age, hypertension, body mass index, number of diseased vessels, and ejection fraction did not fully
explain the excess mortality risk in diabetic women. Excess risk was apparent in both cardiac and noncardiovascular categories.
Among nondiabetic patients, the risk of death was significantly lower in women compared with men (multivariate-adjusted relative
risk = 0.61, 95% CI 0.41-0.89). However, the mortality risk of diabetic women became similar to men as a whole (relative risk
= 1.13, 95% CI 0.80-1.60). CONCLUSIONS--Diabetes confers a substantially higher risk of mortality in women than in men when
it occurs in the presence of coronary heart disease. To evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease OBJECTIVETo evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease.RESEARCH DESIGN AND METHODSCohort study based on a sample from a hospital registry in Chicago, IL. A total of 974 consecutive patients (585 men and 389 women) with angiographically confirmed coronary artery disease were followed for 4.6 yr.RESULTSAt baseline, 160 men and 155 women had diabetes. The age-adjusted relative risk of death from all causes for patients with diabetes versus patients without diabetes was 0.93 (95% confidence interval 0.65-1.34) in men and 1.99 (95% CI 1.30-3.05) in women. For cardiac death, the corresponding relative risk was 1.00 (95% CI 0.64-1.56) and 1.96 (95% CI 1.19-3.24) in men and women, respectively. Baseline differences in age, hypertension, body mass index, number of diseased vessels, and ejection fraction did not fully explain the excess mortality risk in diabetic women. Excess risk was apparent in both cardiac and noncardiovascular categories. Among nondiabetic patients, the risk of death was significantly lower in women compared with men (multivariate-adjusted relative risk = 0.61, 95% CI 0.41-0.89). However, the mortality risk of diabetic women became similar to men as a whole (relative risk = 1.13, 95% CI 0.80-1.60).CONCLUSIONSDiabetes confers a substantially higher risk of mortality in women than in men when it occurs in the presence of coronary heart disease. To evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease. Cohort study based on a sample from a hospital registry in Chicago, IL. A total of 974 consecutive patients (585 men and 389 women) with angiographically confirmed coronary artery disease were followed for 4.6 yr. At baseline, 160 men and 155 women had diabetes. The age-adjusted relative risk of death from all causes for patients with diabetes versus patients without diabetes was 0.93 (95% confidence interval 0.65-1.34) in men and 1.99 (95% CI 1.30-3.05) in women. For cardiac death, the corresponding relative risk was 1.00 (95% CI 0.64-1.56) and 1.96 (95% CI 1.19-3.24) in men and women, respectively. Baseline differences in age, hypertension, body mass index, number of diseased vessels, and ejection fraction did not fully explain the excess mortality risk in diabetic women. Excess risk was apparent in both cardiac and noncardiovascular categories. Among nondiabetic patients, the risk of death was significantly lower in women compared with men (multivariate-adjusted relative risk = 0.61, 95% CI 0.41-0.89). However, the mortality risk of diabetic women became similar to men as a whole (relative risk = 1.13, 95% CI 0.80-1.60). Diabetes confers a substantially higher risk of mortality in women than in men when it occurs in the presence of coronary heart disease. |
| Author | Ghali, J.K Lansky, D Lee, J Cao, G Cooper, R.S Liao, Y. (Loyola University Medical Center, Maywood, IL) |
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| Keywords | Endocrinopathy Human Concomitant disease Diabetes mellitus Risk factor Sex Cardiovascular disease Coronary heart disease Epidemiology Survival |
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| Snippet | To evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease Sex differences in the impact of coexistent diabetes on survival in patients with coronary heart disease. Y Liao , R S Cooper , J K Ghali , D Lansky , G Cao... To evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease. Cohort study based on a sample from a hospital... OBJECTIVETo evaluate the sex difference in the impact of diabetes on survival in patients with coronary heart disease.RESEARCH DESIGN AND METHODSCohort study... |
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| SubjectTerms | Age Factors Biological and medical sciences Body Mass Index Cause of Death Coronary Disease - complications Coronary Disease - mortality DIABETE DIABETES Diabetes Complications Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Follow-Up Studies Hospitals, General Humans Male Medical sciences Middle Aged Registries Risk Factors Sex Characteristics Sex Factors SEXE SEXO Survival Analysis Time Factors TRASTORNOS CIRCULATORIOS TROUBLE CIRCULATOIRE |
| Title | Sex differences in the impact of coexistent diabetes on survival in patients with coronary heart disease |
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