Cell lineage-guided mass spectrometry reveals increased energy metabolism and reactive oxygen species in the vertebrate organizer

Molecular understanding of the vertebrate Organizer, a tissue center critical for inductive signaling during gastrulation, has so far been mostly limited to transcripts and a few proteins, the latter due to limitations in detection and sensitivity. The Spemann-Mangold Organizer (SMO) in the South Af...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 121; no. 6; p. e2311625121
Main Authors:	Baxi, Aparna B, Li, Jie, Quach, Vi M, Pade, Leena R, Moody, Sally A, Nemes, Peter
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 06-02-2024
Subjects:	Animals Biological Sciences Body Patterning - genetics Cell Lineage Central nervous system Developmental biology Embryos Energy Metabolism Gastrulation Gene Expression Regulation, Developmental Hydrogen peroxide Intermediates Mass spectrometry Mass spectroscopy Mesoderm Metabolism Metabolites Metabolomics Organizers, Embryonic - physiology Oxidative phosphorylation Oxidative stress Oxygen enrichment Pattern formation Patterning Phosphorylation Physical Sciences Proteins Proteomics Reactive oxygen species Reactive Oxygen Species - metabolism Regulatory proteins Scientific imaging Transcription Factors - metabolism Vertebrates Xenopus laevis - metabolism Xenopus Proteins - metabolism Xenopus mass spectrometry Spemann–Mangold Organizer proteomics metabolomics
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