A complex satellite DNA polymorphism flanking the human ryanodine receptor gene (RYR1)

We describe a new highly polymorphic DNA marker flanking the human ryanodine receptor gene (RYR1) at chromosome band 19q13.1. The marker is composed of a 25bp minisatellite sequence, a compound microsatellite (AC)(AT), and an oligo-T stretch. STS mapping of previously published markers from 19q13.1...

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Bibliographic Details
Published in:	Cytogenetics and cell genetics Vol. 72; no. 2-3; p. 215
Main Authors:	Wolz, W, Wendelmuth, U, Rouquier, S, Giorgi, D, Müller, C R
Format:	Journal Article
Language:	English
Published:	Switzerland 01-01-1996
Subjects:	Base Sequence Calcium Channels - genetics DNA, Satellite - genetics Humans Molecular Sequence Data Muscle Proteins - genetics Polymerase Chain Reaction Polymorphism, Genetic Ryanodine Receptor Calcium Release Channel
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Summary:	We describe a new highly polymorphic DNA marker flanking the human ryanodine receptor gene (RYR1) at chromosome band 19q13.1. The marker is composed of a 25bp minisatellite sequence, a compound microsatellite (AC)(AT), and an oligo-T stretch. STS mapping of previously published markers from 19q13.1 helped to integrate the genetic and physical maps of this region. Together with D19S422, the new polymorphism forms a pair of markers closely flanking either side of the RYR1 gene which may be useful for linkage studies in families susceptible to malignant hyperthermia and central core disease.
ISSN:	0301-0171
DOI:	10.1159/000134193