Genetic Testing for Warfarin Therapy Initiation

Objective To review the literature regarding the efficacy of genetic testing for determining the appropriate initial dose of warfarin and the effect that this testing has on the safety and efficacy of therapy. Data Sources: Searches of MEDLINE (1966–May 2008) and Cochrane Database (1993–May 2008) we...

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Bibliographic Details
Published in:	The Annals of pharmacotherapy Vol. 42; no. 9; pp. 1298 - 1303
Main Authors:	Hynicka, Lauren M, Cahoon, William D, Jr, Bukaveckas, Bonny L
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA Harvey Whitney Books 01-09-2008 SAGE Publications Whitney
Subjects:	Anticoagulants - adverse effects Biological and medical sciences Genetic Predisposition to Disease Hemorrhage - chemically induced Hemorrhage - genetics Humans Medical sciences Pharmacology. Drug treatments Warfarin - adverse effects VKORC1 CYP2C9 pharmacogenomics pharmacogenetics anticoagulation warfarin Human Pharmacogenetics Warfarin Enzyme Isozyme Coumarine derivatives Cytochrome P450 Genomics VKORC1 gene Anticoagulant Predictive medicine Antivitamin K Treatment Vitamin-K-epoxide reductase (warfarin-sensitive) Genetics Oxidoreductases Initiation CYP2C9 gene Pharmacogenomics
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