Disease-associated astrocyte epigenetic memory promotes CNS pathology

Disease-associated astrocyte subsets contribute to the pathology of neurologic diseases, including multiple sclerosis and experimental autoimmune encephalomyelitis 1 – 8 (EAE), an experimental model for multiple sclerosis. However, little is known about the stability of these astrocyte subsets and t...

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Published in:	Nature (London) Vol. 627; no. 8005; pp. 865 - 872
Main Authors:	Lee, Hong-Gyun, Rone, Joseph M., Li, Zhaorong, Akl, Camilo Faust, Shin, Seung Won, Lee, Joon-Hyuk, Flausino, Lucas E., Pernin, Florian, Chao, Chun-Cheih, Kleemann, Kilian L., Srun, Lena, Illouz, Tomer, Giovannoni, Federico, Charabati, Marc, Sanmarco, Liliana M., Kenison, Jessica E., Piester, Gavin, Zandee, Stephanie E. J., Antel, Jack P., Rothhammer, Veit, Wheeler, Michael A., Prat, Alexandre, Clark, Iain C., Quintana, Francisco J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28-03-2024 Nature Publishing Group
Subjects:	45/15 45/23 45/44 45/91 631/250/371 631/378/1689 Accessibility Acetyl Coenzyme A - metabolism Animals Astrocytes Astrocytes - enzymology Astrocytes - metabolism Astrocytes - pathology ATP Citrate (pro-S)-Lyase - metabolism Autoimmune diseases Chromatin Chromatin - genetics Chromatin - metabolism Chromatin Assembly and Disassembly Chromatin Immunoprecipitation Sequencing Coenzyme A CRISPR CRISPR-Cas Systems Cytokines Disease Encephalomyelitis, Autoimmune, Experimental - enzymology Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Epigenetic Memory Epigenetics Experimental allergic encephalomyelitis Female Gene expression Gene sequencing Histone acetyltransferase Humanities and Social Sciences Humans Immunohistochemistry Immunoprecipitation In vivo methods and tests Inactivation Inflammation Inflammation - enzymology Inflammation - genetics Inflammation - metabolism Inflammation - pathology Interrogation Lymphocytes Male Metabolism Mice multidisciplinary Multiple sclerosis Multiple Sclerosis - enzymology Multiple Sclerosis - genetics Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Neurological diseases Nucleic acids Pathology Phenotypes Ribonucleic acid RNA Science Science (multidisciplinary) Single-Cell Gene Expression Analysis Transposase Transposases - metabolism
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