The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma

• Published in: Clinical biochemistry Vol. 37; no. 12; pp. 1117 - 1120
• Main Authors: Gurel, Ahmet, Tomac, Nazan, Ramazan Yilmaz, H., Tekedereli, Ibrahim, Akyol, Omer, Armutcu, Ferah, Yuce, Huseyin, Akin, Haluk, Ozcelik, Nurten, Elyas, Halit
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-12-2004
• Subjects: Adolescent; Age of Onset; Alanine - genetics; Asthma; Asthma - genetics; Case-Control Studies; Child; Child, Preschool; Genotype; Humans; Infant; Manganese; Manganese superoxide dismutase; Mitochondria - metabolism; Oxidative Stress; Peptides - chemistry; Peptides - genetics; Polymorphism; Polymorphism, Genetic; Superoxide Dismutase - genetics; Superoxide Dismutase - metabolism; Valine - genetics; Oxidative stress; GSH-Px; ROS; SOD; MTS; PCR; Asthma; Manganese superoxide dismutase; Polymorphism
• ISSN: 0009-9120; 1873-2933
• DOI: 10.1016/j.clinbiochem.2004.08.002

We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma.
Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with
NgoM IV.
No significant difference in genotype frequencies was found between patients and controls.
These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma.