The Pharmacokinetics in Mice and Cell Uptake of Thymus Immunosuppressive Pentapeptide Using LC-MS/MS Analysis

Thymus immunosuppressive pentapeptide (TIPP) is a novel anti-inflammatory peptide with high efficacy and low toxicity. This study aims to establish a selective LC-MS/MS method for analyzing the analyte TIPP in biological samples, laying the foundation for further PK and PD studies of TIPP. Protein p...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 13; p. 4256
Main Authors:	Chen, Shang, Ren, Chenyan, Ji, Yuan, Liu, Dongke, Zhang, Xinke, Wang, Fengshan
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-07-2022 MDPI
Subjects:	Accuracy Acetonitrile allergic asthma Animals Aqueous solutions Asthma Backwash bioanalytical method development Biocompatibility Biological properties Biological samples Cell culture cell uptake Chromatography Chromatography, Liquid - methods Dichloromethane Dithiothreitol Formic acid Immunoassay Immunosuppressive Agents - analysis In vivo methods and tests Inflammation Intracellular Ionization LC-MS/MS Lysates Mice Peptides Pharmacokinetics Pharmacology Plasma Plasma - chemistry Proteins Quality control Quantitative analysis Reproducibility of Results Tandem Mass Spectrometry - methods Thymus Thymus gland Thymus Plant Toxicity pharmacokinetics LC-MS/MS allergic asthma bioanalytical method development cell uptake
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