Complex Interplay Between Metabolism and CD4+ T-Cell Activation, Differentiation, and Function: a Novel Perspective for Atherosclerosis Immunotherapy

Atherosclerosis is a complex pathological process that results from the chronic inflammatory reaction of the blood vessel wall and involves various immune cells and cytokines. An imbalance in the proportion and function of the effector CD4 + T-cell (Teff) and regulatory T-cell (Treg) subsets is an i...

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Bibliographic Details
Published in:	Cardiovascular drugs and therapy Vol. 38; no. 5; pp. 1033 - 1046
Main Authors:	Yang, Jingmin, Chen, Yanying, Li, Xiao, Qin, Huali, Bao, Jinghui, Wang, Chunfang, Dong, Xiaochen, Xu, Danyan
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-10-2024 Springer Nature B.V
Subjects:	AMP-Activated Protein Kinases - metabolism Animals Arteriosclerosis Atherosclerosis Atherosclerosis - immunology Atherosclerosis - metabolism Blood vessels Cardiology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell activation Cell Differentiation Cell proliferation Differentiation (biology) Effector cells Energy metabolism Energy Metabolism - drug effects Glutamine Glycolysis Humans Immune system Immunotherapy Immunotherapy - methods Lymphocyte Activation Lymphocytes Lymphocytes T Medicine Medicine & Public Health Metabolic pathways Metabolic rate Metabolism Oxidation Review Article Signal Transduction T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism TOR protein TOR Serine-Threonine Kinases - metabolism mTOR Immunometabolism AMPK CD4 T cell Atherosclerosis CD4+ T cell
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