The M4 insulator, the TM2 matrix attachment region, and the double copy of the heavy chain gene contribute to the enhanced accumulation of the PHB-01 antibody in tobacco plants

The expression of recombinant proteins in plants is a valuable alternative to bioreactors using mammalian cell systems. Ease of scaling, and their inability to host human pathogens, enhance the use of plants to generate complex therapeutic products such as monoclonal antibodies. However, stably tran...

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Bibliographic Details
Published in:	Transgenic research Vol. 29; no. 2; pp. 171 - 186
Main Authors:	Ruiz, Yoslaine, Ramos, Pedro Luis, Soto, Jeny, Rodríguez, Meilyn, Carlos, Natacha, Reyes, Aneisi, Callard, Danay, Sánchez, Yadira, Pujol, Merardo, Fuentes, Alejandro
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01-04-2020 Springer Nature B.V
Subjects:	Animal Genetics and Genomics Antibodies - genetics Antibodies - metabolism Biomedical and Life Sciences Biomedical Engineering/Biotechnology Bioreactors Chromatin Deoxyribonucleic acid DNA Gene Expression Regulation, Plant Genetic Engineering Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Immunoglobulin Light Chains - genetics Immunoglobulin Light Chains - metabolism Insulator Elements Life Sciences Matrix attachment regions Matrix Attachment Regions - genetics Molecular Medicine Monoclonal antibodies Nicotiana - genetics Nicotiana - growth & development Original Paper Plant Genetics and Genomics Plants, Genetically Modified - genetics Plants, Genetically Modified - growth & development Prohibitins Promoter Regions, Genetic Recombinant Proteins - genetics Recombinant Proteins - metabolism Tobacco Transcription Transgenes Transgenes - genetics Transgenic plants Transgenics Plant expression Tobacco Insulator Antibody Matrix attachment region
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