Effects of vitamin B12 on methotrexate hepatotoxicity: evaluation of receptor-interacting protein (RIP) kinase

In the study, we aimed to show the effects of vitamin B12 on the necrosis caused by methotrexate (MTX), a folic acid antagonist. Thirty-two rats were randomly assigned to four groups of eight rats per group. Control ( n = 8), Vit B12 ( n = 8) 3 μg/kg/ip B12 (15 days) per day throughout the experimen...

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Bibliographic Details
Published in:	Naunyn-Schmiedeberg's archives of pharmacology Vol. 393; no. 12; pp. 2473 - 2480
Main Authors:	Karabulut, Derya, Ozturk, Emel, Kuloglu, Nurhan, Akin, Ali Tuğrul, Kaymak, Emin, Yakan, Birkan
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2020 Springer Nature B.V
Subjects:	Antioxidants Biomedical and Life Sciences Biomedicine Cyclooxygenase-2 Experiments Folic acid Hepatotoxicity Immunohistochemistry Kinases Methotrexate Neurosciences Original Article Oxidants Pharmacology/Toxicology Protein kinase Tumor necrosis factor-α Vitamin B12 Receptor-interacting protein kinase Methotrexate Vitamin B12
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