Identifying risk factors of intracerebral hemorrhage stability using explainable attention model

• Published in: Medical & biological engineering & computing Vol. 60; no. 2; pp. 337 - 348
• Main Authors: Rangaraj, Seshasayi, Islam, Mobarakol, VS, Vibashan, Wijethilake, Navodini, Uppal, Utkarsh, See, Angela An Qi, Chan, Jasmine, James, Michael Lucas, King, Nicolas Kon Kam, Ren, Hongliang
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2022; Springer Nature B.V
• Subjects: Accuracy; Angiography; Attention; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Cerebral Hemorrhage - diagnostic imaging; Computed Tomography Angiography; Computer Applications; Feature extraction; Glasgow Coma Scale; Hemorrhage; Human Physiology; Humans; Imaging; Learning algorithms; Machine learning; Multilayer perceptrons; Original Article; Patients; Radiology; Risk analysis; Risk Factors; Segmentation; Stability; Stroke; Support vector machines; 3D CNN; Risk prediction; Attention network; Growth rate estimation; Segmentation; Intracerebral hemorrhage
• ISSN: 0140-0118; 1741-0444
• DOI: 10.1007/s11517-021-02459-y

Segmentation of intracerebral hemorrhage (ICH) helps improve the quality of diagnosis, draft the desired treatment methods, and clinically observe the variations with healthy patients. The clinical utilization of various ICH progression scoring systems has limitations due to the systems’ modest predictive value. This paper proposes a single pipeline of a multi-task model for end-to-end hemorrhage segmentation and risk estimation. We introduce a 3D spatial attention unit and integrate it into the state-of-the-art segmentation architecture, UNet, to enhance the accuracy by bootstrapping the global spatial representation. We further extract the geometric features from the segmented hemorrhage volume and fuse them with clinical features such as CT angiography (CTA) spot, Glasgow Coma Scale (GCS), and age to predict the ICH stability. Several state-of-the-art machine learning techniques such as multilayer perceptron (MLP), support vector machine (SVM), gradient boosting, and random forests are applied to train stability estimation and to compare the performances. To align clinical intuition with model learning, we determine the shapely values (SHAP) and explain the most significant features for the ICH risk scoring system. A total of 79 patients are included, of which 20 are found in critical condition. Our proposed single pipeline model achieves a segmentation accuracy of 86.3%, stability prediction accuracy of 78.3%, and precision of 82.9%; the mean square error of exact expansion rate regression is observed to be 0.46. The SHAP analysis reveals that CTA spot sign, age, solidity, location, and length of the first axis of the ICH volume are the most critical characteristics that help define the stability of the stroke lesion. We also show that integrating significant geometric features with clinical features can improve the ICH progression scoring by predicting long-term outcomes.
Graphical abstract
Overview of our proposed method comprising of spatial attention and feature extraction mechanisms. The architecture is trained on the input CT images, and the first step output is the predicted segmentation of the hemorrhagic region. The output is fed into a geometric feature extractor and is fused with clinical features to estimate ICH stability using a multilayer perceptron (MLP)