Characterization and functional roles of KCNQ-encoded voltage-gated potassium (Kv7) channels in human corpus cavernosum smooth muscle

The group of KCNQ-encoded voltage-gated potassium (Kv7) channels includes five family members (Kv7.1–7.5). We examined the molecular expression and functional roles of Kv7 channels in corporal smooth muscle (CSM). Isolated rabbit CSM strips were mounted in an organ bath system to characterize Kv7 ch...

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Bibliographic Details
Published in:	Pflügers Archiv Vol. 472; no. 1; pp. 89 - 102
Main Authors:	Lee, Jun Ho, Chae, Mee Ree, Kang, Su Jeong, Sung, Hyun Hwan, Han, Deok Hyun, So, Insuk, Park, Jong Kwan, Lee, Sung Won
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 2020 Springer Nature B.V
Subjects:	Anilides - pharmacology Animals Anthracenes - pharmacology Biomedical and Life Sciences Biomedicine Bridged Bicyclo Compounds - pharmacology Calcium (intracellular) Cell Biology Cell membranes Cells, Cultured Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Endothelium Enzyme inhibitors Erectile dysfunction Human Physiology Humans Hydrazones - pharmacology Ion Channels Isoquinolines - pharmacology Isoxazoles - pharmacology KCNQ1 protein KCNQ4 protein Kinases Male Membrane potential Molecular Medicine Muscle Contraction Muscle Relaxation Muscle, Smooth - cytology Muscle, Smooth - metabolism Muscle, Smooth - physiology Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - physiology Neurosciences Penis - cytology Potassium Potassium Channel Blockers - pharmacology Potassium channels Potassium channels (voltage-gated) Potassium Channels, Voltage-Gated - antagonists & inhibitors Potassium Channels, Voltage-Gated - metabolism Protein kinase A Protein kinase A inhibitors Protein Kinase Inhibitors - pharmacology Rabbits Rats Receptors Receptors and Transporters Smooth muscle Sulfonamides - pharmacology KCNQ Corpus cavernosum Erectile dysfunction Kv7.4 channel KCNE
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