The interaction between liver cirrhosis, infection by Streptococcus bovis, and colon cancer

• Published in: European journal of clinical microbiology & infectious diseases Vol. 42; no. 7; pp. 907 - 912
• Main Authors: Corredoira, Juan, Miguez, Enrique, Mateo, Lara María, Fernández-Rodríguez, Ricardo, García-Rodríguez, José Francisco, Pérez-González, Alexandre, Sanjurjo, Ana, Pulian, María Victoria, Ayuso-García, Blanca
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2023; Springer Nature B.V
• Subjects: Bacteremia; Bacteria; Biomedical and Life Sciences; Biomedicine; Brief Report; Cirrhosis; Cohort analysis; Colon cancer; Colonoscopy; Colorectal cancer; Endocarditis; Hospitals; Infectious diseases; Internal Medicine; Liver cirrhosis; Liver diseases; Medical Microbiology; Microbiology; Microorganisms; Mortality; Neoplasia; Neoplasms; Nosocomial infections; Statistical analysis; Streptococcus bovis; Streptococcus infections; Tumors; Colorectal neoplasm; Bacteriemia; Liver cirrhosis; Colonoscopy; Streptococcus bovis
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-023-04618-5

Whether cirrhotic patients with
Streptococcus bovis
bacteremia have an increased risk of colorectal neoplasm is uncertain. A multicentric retrospective cohort study was conducted investigating associations between
S. bovis
biotype and species, cirrhosis, and colorectal neoplasm. Out of 779 patients with
S. bovis
bacteremia, 69 (8.7%) had cirrhosis. No differences were found in the prevalence of colorectal neoplasm between cirrhotic and non-cirrhotic patients undergoing colonoscopy. Among cirrhotic patients, prevalence of colorectal neoplasms was higher in
S. bovis
biotype I (
S. gallolyticus
) bacteremia (80%) than in
S. bovis
biotype II (33.3%;
p
 < 0.007). In conclusion, risk of colorectal neoplasm is high among cirrhotic patients with
S. gallolyticus
bacteremia.