Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands

• Published in: International ophthalmology Vol. 42; no. 4; pp. 1101 - 1109
• Main Authors: de Lima-Souza, Reydson Alcides, Rodrigues, Natália de Magalhães, Scarini, João Figueira, Silva, Mário Fernandez Sobral, Tincani, Alfio José, Egal, Erika Said Abu, Altemani, Albina, Mariano, Fernanda Viviane
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-04-2022; Springer Nature B.V
• Subjects: Adenocarcinoma - metabolism; Adenoma; Adenoma, Pleomorphic; Cancer; Carcinoma - pathology; Exocrine glands; Glycolysis; Humans; Hypoxia-inducible factor 1a; Lacrimal Apparatus - pathology; Lacrimal gland and Nasolacrimal duct; Lipid metabolism; Lipids; Lipogenesis; Medicine; Medicine & Public Health; Metabolism; Ophthalmology; Original Paper; Perilipin-2; Tumors; Glycogenesis; Lacrimal glands; Carcinoma ex pleomorphic adenoma; Metabolism; Lipogenesis; Pleomorphic adenoma
• ISSN: 1573-2630; 0165-5701; 1573-2630
• DOI: 10.1007/s10792-021-02096-2

Purpose
To evaluate metabolic alterations along with the carcinoma ex pleomorphic adneoma (CXPA) development of lacrimal glands (LG).
Methods
Four samples of the normal LG (NLG), 9 of pleomorphic adenoma (PA), 4 of residual PA (rPA), and 4 of CXPA of LG were included. GLUT-1, HIF-1α, FASN, and adipophilin by immunohistochemical stains were performed in the selected cases.
Results
Was observed higher expression of markers associated with glycolytic and lipid metabolism in the tumor tissue samples when compared to the NLG samples. Additionally, GLUT-1, FASN, and Adipophilin were more expressed in CXPA samples while HIF-1α in PA samples.
Conclusions
In conclusion, our results demonstrate overexpression of FASN and Adipophilin in CXPA which may reflect a metabolic shift toward lipogenesis in cancer cells.