Cell signaling pathways as molecular targets to eliminate AML stem cells

Cell signaling pathways as molecular targets to eliminate AML stem cells

•Acute myeloid leukemia remains the most lethal of leukemias.•Leukemic stem cells are associated with disease relapses.•Cell signaling pathways are targets to eliminate AML stem cells. Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic s...

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Published in:Critical reviews in oncology/hematology Vol. 160; p. 103277
Main Authors: Rodrigues, Ana Carolina B. da C., Costa, Rafaela G.A., Silva, Suellen L.R., Dias, Ingrid R.S.B., Dias, Rosane B., Bezerra, Daniel P.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-04-2021
Subjects:
Acute myeloid leukemia
Cell signaling
Humans
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Leukemic stem cells
Neoplastic Stem Cells - metabolism
NF-kappa B - metabolism
Phosphatidylinositol 3-Kinases
Signal Transduction
Target therapy
LTC-IC
IRS1
RANK
IL-1R
[PtdIns (3,4,5)P3] (PIP3)
AP-1
PLZF
TNF
Frz
PI3K
PPAR
GSK3
IGFR-1
PPRE
R-SMAD
CK1α
VPS34
MUC1-C
IL
TKIs
GMP
Ara-C
RUNX1
BCR
BAFFR
LPA
PDK-1
DMAPT
ERK
DNMT1
FDA
BM
LTβR
β-TRCP
SCID
Cell signaling
GPCRs
Leukemic stem cells
PDGFR
miRNA
Wnt
BMP
TNFSF13
IKK
STAT
LSCs
TBL1
RHEB
ITD
ATM
ETO
FLT3
JNK
TGFs
PTEN
MLL
NF-κB
PYGO
mTOR
RARa
VEGFR
AMH
MDS
AML
NOD
HSP
TSC
DNMT3A
IGF-1
GDFs
TYK2
I-SMADs
TCF
ROS
PCP
PI-103
Acute myeloid leukemia
[PtdIns (4,5)P2] (PIP2)
TCR
Target therapy
A-PACs
XIAP
RXR
Raptor
Co-SMAD
TLR
IFNs
CEBPa
TNFR
PDX
VEGF
siRNA
LEF
TSGs
LICs
PML
NIK
APC
JAK
PH
HSCs
DVL
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Abstract •Acute myeloid leukemia remains the most lethal of leukemias.•Leukemic stem cells are associated with disease relapses.•Cell signaling pathways are targets to eliminate AML stem cells. Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-κB, Wnt/β-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy.
AbstractList Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-κB, Wnt/β-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy.
•Acute myeloid leukemia remains the most lethal of leukemias.•Leukemic stem cells are associated with disease relapses.•Cell signaling pathways are targets to eliminate AML stem cells. Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with disease relapses. Some cell signaling pathways play an important role in AML survival, proliferation and self-renewal properties and are abnormally activated or suppressed in LSCs. This includes the NF-κB, Wnt/β-catenin, Hedgehog, Notch, EGFR, JAK/STAT, PI3K/AKT/mTOR, TGF/SMAD and PPAR pathways. This review aimed to discuss these pathways as molecular targets for eliminating AML LSCs. Herein, inhibitors/activators of these pathways were summarized as a potential new anti-AML therapy capable of eliminating LSCs to guide future researches. The clinical use of cell signaling pathways data can be useful to enhance the anti-AML therapy.
ArticleNumber 103277
Author Costa, Rafaela G.A.
Bezerra, Daniel P.
Dias, Ingrid R.S.B.
Dias, Rosane B.
Silva, Suellen L.R.
Rodrigues, Ana Carolina B. da C.
Author_xml – sequence: 1
  givenname: Ana Carolina B. da C.
  surname: Rodrigues
  fullname: Rodrigues, Ana Carolina B. da C.
– sequence: 2
  givenname: Rafaela G.A.
  surname: Costa
  fullname: Costa, Rafaela G.A.
– sequence: 3
  givenname: Suellen L.R.
  surname: Silva
  fullname: Silva, Suellen L.R.
– sequence: 4
  givenname: Ingrid R.S.B.
  surname: Dias
  fullname: Dias, Ingrid R.S.B.
– sequence: 5
  givenname: Rosane B.
  surname: Dias
  fullname: Dias, Rosane B.
– sequence: 6
  givenname: Daniel P.
  orcidid: 0000-0002-6774-2063
  surname: Bezerra
  fullname: Bezerra, Daniel P.
  email: daniel.bezerra@fiocruz.br
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33716201$$D View this record in MEDLINE/PubMed
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Keywords LTC-IC
IRS1
RANK
IL-1R
[PtdIns (3,4,5)P3] (PIP3)
AP-1
PLZF
TNF
Frz
PI3K
PPAR
GSK3
IGFR-1
PPRE
R-SMAD
CK1α
VPS34
MUC1-C
IL
TKIs
GMP
Ara-C
RUNX1
BCR
BAFFR
LPA
PDK-1
DMAPT
ERK
DNMT1
FDA
BM
LTβR
β-TRCP
SCID
Cell signaling
GPCRs
Leukemic stem cells
PDGFR
miRNA
Wnt
BMP
TNFSF13
IKK
STAT
LSCs
TBL1
RHEB
ITD
ATM
ETO
FLT3
JNK
TGFs
PTEN
MLL
NF-κB
PYGO
mTOR
RARa
VEGFR
AMH
MDS
AML
NOD
HSP
TSC
DNMT3A
IGF-1
GDFs
TYK2
I-SMADs
TCF
ROS
PCP
PI-103
Acute myeloid leukemia
[PtdIns (4,5)P2] (PIP2)
TCR
Target therapy
A-PACs
XIAP
RXR
Raptor
Co-SMAD
TLR
IFNs
CEBPa
TNFR
PDX
VEGF
siRNA
LEF
TSGs
LICs
PML
NIK
APC
JAK
PH
HSCs
DVL
Language English
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Snippet •Acute myeloid leukemia remains the most lethal of leukemias.•Leukemic stem cells are associated with disease relapses.•Cell signaling pathways are targets to...
Acute myeloid leukemia (AML) remains the most lethal of leukemias and a small population of cells called leukemic stem cells (LSCs) has been associated with...
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Index Database
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StartPage 103277
SubjectTerms Acute myeloid leukemia
Cell signaling
Humans
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Leukemic stem cells
Neoplastic Stem Cells - metabolism
NF-kappa B - metabolism
Phosphatidylinositol 3-Kinases
Signal Transduction
Target therapy
Title Cell signaling pathways as molecular targets to eliminate AML stem cells
URI https://dx.doi.org/10.1016/j.critrevonc.2021.103277
https://www.ncbi.nlm.nih.gov/pubmed/33716201
https://search.proquest.com/docview/2501483197
Volume 160
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