Ruthenium polypyridyl complex-containing bioconjugates

• Published in: Coordination chemistry reviews Vol. 434; p. 213736
• Main Authors: Martínez-Alonso, Marta, Gasser, Gilles
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-05-2021; Elsevier
• Subjects: Bioconjugates; Bioinorganic chemistry; Chemical Sciences; Inorganic chemical biology; Medicinal Chemistry; Medicinal inorganic chemistry; Ruthenium Polypyridyl Complexes; PNA; STD; BBB; PS; MeCN; PACT; HLF-a; MPP; TFA; BBN; MPT; DCBQ; Sp2/0-Ag 14; AQC; LS174T; IC50; ptrpy; MDCK; DMPC; SATA; AA; MCTSs; AQS; amol; H2TPP; SiHa; DAPI; Bioinorganic chemistry; DAPA; RCA; RF; 6; Ig; ConA; ABDA; BDC; Ab; ABC; CALI; TPA; MCF-7; PSII; FLIM; BM; BQ; BR; HeLa; Abs; NLS; TCNQ; TPP; L929; Biqbpy; MBQ; CA; DMPG; CD; DABA; Inorganic chemical biology; dpp; GLUT; TA; CaSki; 5Bpy; mAb; WGA; AE9a; CV; A549R; CCOx; dmbpy; VDAC; ITC; LF; TP; tpy; ABTS; MDA-MB-231; ADC; CPP; LLIM; Medicinal inorganic chemistry; CHO; MtMP; eT; CT-DNA; phen; RNS; HSA; EC50; CLSM; PS140-b-PAA48; AML; PBS; dcbpy; dppn; MV; YDS; dppg; ER; MTs; RGD; CsA; NA; NB; Bioconjugates; HT-29; Mb; MeOH; ROS; dppz; FA; VEGFR2; TTC; NQ; DTT; IgG; FP; LDC; EGFR; 3T3; PLPG; HepG2; NHS; Ect1/E6E7; DMF; ICmin; hdpa; PDT; biptpy; Htme; STED; VEGF; bpy; SSTRs; β-CD; B16F10; SST; Ruthenium Polypyridyl Complexes; PI; PEO; HaCaT
• ISSN: 0010-8545; 1873-3840; 0010-8545
• DOI: 10.1016/j.ccr.2020.213736

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•Bioconjugation improves some of the features of Ru(II) polypyridyl complexes•The intrinsic properties of the complexes are not usually altered by the bioconjugation.•Peptides are among the most common biomolecules used in bioconjugation with Ru(II) complexes.•The bioconjugates were used for different purposes.
In the last decades, the number of articles describing the synthesis, characterization and applications of ruthenium polypyridyl complexes has significantly increased. One of the reasons is their tuneable, outstanding luminescent properties. However, ruthenium polypyridyl complexes usually have no intrinsic selectivity towards cancer cells, making them impractical, for example, in certain biological applications. To overcome this drawback, these complexes have been conjugated to biomolecules. In this review, we describe the different ruthenium polypyridyl complex-containing bioconjugates reported so far and their applications as, for example, anticancer drug candidates, sensors or biocatalysts. However, we are not reviewing ruthenium-containing nucleotides and DNA conjugates since these topics were recently reported. The multiple ways of attaching the biomolecules (i.e., peptides, antibodies, carbohydrates, lipids and vitamins) to the ruthenium core are also summarized.