Knee arthrography: a comparison of iohexol, ioxaglate sodium meglumine, and metrizoate

The arthrographic image quality and relative morbidity resulting from use of Omnipaque 300 (iohexol), Hexabrix 320 (ioxaglate sodium meglumine), and Isopaque Coronar 370 (metrizoate) were compared in a prospective double-blind study performed with 120 patients. Radiographs obtained 2, 5, 10, 15, 20,...

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Bibliographic Details
Published in:	Radiology Vol. 162; no. 3; p. 729
Main Authors:	Obermann, W R, Kieft, G J
Format:	Journal Article
Language:	English
Published:	United States 01-03-1987
Subjects:	Adolescent Adult Arthrography Child Clinical Trials as Topic Double-Blind Method Female Humans Iodobenzoates Iohexol Ioxaglic Acid Knee - diagnostic imaging Male Metrizoic Acid - analogs & derivatives Middle Aged
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Summary:	The arthrographic image quality and relative morbidity resulting from use of Omnipaque 300 (iohexol), Hexabrix 320 (ioxaglate sodium meglumine), and Isopaque Coronar 370 (metrizoate) were compared in a prospective double-blind study performed with 120 patients. Radiographs obtained 2, 5, 10, 15, 20, and 25 minutes after injection were judged for diagnostic quality. Relative morbidity was evaluated by the physician during the examination and later by the patient via a questionnaire. Hexabrix demonstrated the best and most persistent diagnostic quality over serial radiographs (P less than .05). Omnipaque caused significantly less postprocedural pain (P less than .05). The other types of discomfort measured did not indicate statistically significant differences in morbidity resulting from the three contrast agents.
ISSN:	0033-8419
DOI:	10.1148/radiology.162.3.3544035