Benzyl alcohol inhibits N-methyl-D: -aspartate receptor-mediated neurotoxicity and calcium accumulation in cultured rat cortical neurons

The purpose of this study is to examine whether benzyl alcohol affects N-methyl-D-aspartate (NMDA) receptor in cortical cells. Benzyl alcohol (0.5-2 mM) inhibited NMDA-induced cytotoxicity. The protective effect of benzyl alcohol on NMDA-induced toxicity disappeared by washing cells with buffer to r...

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Bibliographic Details
Published in:	Journal of biomedical science Vol. 15; no. 6; p. 767
Main Authors:	Takadera, Tsuneo, Ohyashiki, Takao
Format:	Journal Article
Language:	English
Published:	England 01-11-2008
Subjects:	Anesthetics, Local - pharmacology Animals Benzyl Alcohol - pharmacology Calcium - metabolism Cells, Cultured Cerebral Cortex - drug effects Excitatory Amino Acid Agonists - toxicity N-Methylaspartate - toxicity Neurons - drug effects Rats Receptors, N-Methyl-D-Aspartate - metabolism Time Factors
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Summary:	The purpose of this study is to examine whether benzyl alcohol affects N-methyl-D-aspartate (NMDA) receptor in cortical cells. Benzyl alcohol (0.5-2 mM) inhibited NMDA-induced cytotoxicity. The protective effect of benzyl alcohol on NMDA-induced toxicity disappeared by washing cells with buffer to remove benzyl alcohol. Benzyl alcohol reduced NMDA receptor-mediated calcium accumulation, indicating that benzyl alcohol inhibits NMDA receptor activity.
ISSN:	1423-0127
DOI:	10.1007/s11373-008-9276-5