Distal tubular dysfunction in lupus nephritis of childhood and adolescence

• Published in: Pediatric nephrology (Berlin, West) Vol. 13; no. 9; pp. 846 - 849
• Main Authors: HATAYA, H, IKEDA, M, IDE, Y, KOBAYASHI, Y, KURAMOCHI, S, AWAZU, M
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01-11-1999; Springer Nature B.V
• Subjects: Acidosis; Acidosis, Renal Tubular - blood; Acidosis, Renal Tubular - complications; Acidosis, Renal Tubular - pathology; Adolescent; Adolescents; Aldosterone - blood; Biological and medical sciences; Child; Children; Creatinine - blood; Female; Furosemide - metabolism; Humans; Hydrogen-Ion Concentration; Hypoaldosteronism; Hypoaldosteronism - blood; Hypoaldosteronism - complications; Hypoaldosteronism - pathology; Kidney - ultrastructure; Lupus; Lupus nephritis; Lupus Nephritis - blood; Lupus Nephritis - complications; Lupus Nephritis - pathology; Medical sciences; Microscopy, Electron; Nephritis; Patients; Pediatrics; Potassium - blood; Renal tubular acidosis; Renin - blood; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Systemic lupus erythematosus; Endocrinopathy; Human; Kidney disease; Immunopathology; Connective tissue disease; Skin disease; Urinary system disease; Adrenal cortex diseases; Tubulopathy; Autoimmune disease; Hypoaldosteronism; Hyporeninemia; Case study; Adrenal insufficiency; Systemic disease; Adrenal gland diseases; Complication; Female; Lupus erythematosus; Disseminated; Acidosis; Child
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s004670050713

We describe a girl with lupus nephritis who presented with distal renal tubular acidosis and hyporeninemic hypoaldosteronism. While distal tubular dysfunction is well recognized in adult systemic lupus erythematosus (SLE), only a few pediatric patients have been reported. Evaluation of five pediatric patients with SLE revealed that distal tubular dysfunction in childhood and adolescence is rare.