First synthesis of 3,3-difluoroserine and cysteine derivatives via Mg(0)-promoted selective CF bond cleavage of trifluoromethylimines

First synthesis of 3,3-difluoroserine and cysteine derivatives via Mg(0)-promoted selective CF bond cleavage of trifluoromethylimines

3,3-Difluoroserine and cysteine derivatives were synthesized via Mg(0)-promoted defluorination of trifluoromethylimines as a key step, followed by addition of alcohols and sulfenyl chloride, respectively.

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Bibliographic Details
Published in:Tetrahedron letters Vol. 41; no. 41; pp. 7893 - 7896
Main Authors: Mae, Masayuki, Amii, Hideki, Uneyama, Kenji
Format: Journal Article
Language:English
Published: Elsevier Ltd 07-10-2000
Subjects:
amino acids
defluorination
enamines
imines
imines
enamines
defluorination
amino acids
Online Access:Get full text
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Description
Summary:3,3-Difluoroserine and cysteine derivatives were synthesized via Mg(0)-promoted defluorination of trifluoromethylimines as a key step, followed by addition of alcohols and sulfenyl chloride, respectively.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)01350-2