T Cell Responses to Heat-Shock Protein 60: Differential Responses by CD4+ T Cell Subsets According to Their Expression of CD45 Isotypes

We demonstrate that human T lymphocytes proliferate in vitro to highly purified human heat-shock protein 60 (Hu.hsp60). The response to this self Ag was confined to the CD45RA+ RO- T cell subset, with minimal responses by adult CD45RA- RO+ T cells. Experiments using keyhole limpet hemocyanin as a pr...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 162; no. 2; pp. 704 - 710
Main Authors:	Ramage, Judith M, Young, Joyce L, Goodall, Jane C, Hill Gaston, J. S
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 15-01-1999
Subjects:	Adult Animals Bacterial Proteins - immunology Bacterial Proteins - pharmacology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Chaperonin 60 - pharmacology Epitopes, T-Lymphocyte - pharmacology Haptens - immunology Hemocyanins - immunology Humans Immunologic Memory Leukocyte Common Antigens - biosynthesis Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocyte Activation - drug effects Mollusca - immunology Mycobacterium bovis - immunology Protein Isoforms - biosynthesis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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