A tribute to D'Arcy Wentworth Thompson: Elucidation of a developmental principle

We show the vertebrate anterior –posterior axis is made by time space translation (TST). 1/ TST of Hox temporal to spatial collinearity makes the trunk part of the axis. 2/TST continues into the head. 3/ TST is mediated by collinear Hox‐Hox interactions. 4/ ‘Decision points’ involving signalling pat...

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Bibliographic Details
Published in:	BioEssays Vol. 39; no. 8
Main Authors:	Durston, Antony J., Zhu, Kongju
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-08-2017
Subjects:	Animals Body Patterning - genetics Body Patterning - physiology Collinearity Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Humans Morphogenesis - genetics Morphogenesis - physiology Signal transduction Signaling Vertebrates - embryology Vertebrates - genetics
Online Access:	Get full text
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Summary:	We show the vertebrate anterior –posterior axis is made by time space translation (TST). 1/ TST of Hox temporal to spatial collinearity makes the trunk part of the axis. 2/TST continues into the head. 3/ TST is mediated by collinear Hox‐Hox interactions. 4/ ‘Decision points’ involving signalling pathways separate axial domains.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0265-9247 1521-1878
DOI:	10.1002/bies.201700088