Mild Acidosis‐Directed Signal Amplification in Tumor Microenvironment via Spatioselective Recruitment of DNA Amplifiers

DNA biotechnology offers intriguing opportunities for amplification‐based sensitive detection. However, spatiotemporally‐controlled manipulation of signal amplification for in situ imaging of the tumor microenvironment remains an outstanding challenge. Here, we demonstrate a DNA‐based strategy that...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 61; no. 31; pp. e202205436 - n/a
Main Authors:	Di, Zhenghan, Lu, Xueguang, Zhao, Jian, Jaklenec, Ana, Zhao, Yuliang, Langer, Robert, Li, Lele
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 01-08-2022
Edition:	International ed. in English
Subjects:	Acidosis Amplification Amplifiers Biotechnology Cell Surface Engineering Deoxyribonucleic acid DNA DNA - chemistry DNA Receptors Fluorescence Humans Hybridization Imaging Mild Acidosis Neoplasms Nucleic Acid Hybridization pH effects Recruitment Signal Amplification Tumor cells Tumor Microenvironment Tumors Tumor Microenvironment Mild Acidosis Signal Amplification DNA Receptors Cell Surface Engineering
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